HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ASAP3 (Q8TDY4)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)
Gene: ASAP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	26871637, 33961781, 19380743
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, bimolecular fluorescence complementation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 903
+	Hs
		802877 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ASAP3_HUMAN (1-903): 0: 570: 100.00
+	Hs
		195788 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ASAP2_HUMAN (1-677): 4.54e-148: 465: 53.42
+	Hs
		802771 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ASAP1_HUMAN (1-679): 3.16e-134: 431: 47.89
+	Hs
		802918 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ASAP1_HUMAN (1-679): 3.16e-134: 431: 47.89
+	Hs
		195785 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		ASAP2_HUMAN (1-677): 4.54e-148: 465: 53.42
+	Hs
		195791 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASAP2_HUMAN (1-677): 4.54e-148: 465: 53.42
+	Hs
		275240 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		ASAP1_HUMAN (1-679): 3.16e-134: 431: 47.89
+	Hs
		581076 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		ASAP1_HUMAN (1-679): 3.16e-134: 431: 47.89
+	Hs
		924943 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASAP1_HUMAN (1-679): 3.16e-134: 431: 47.89
+	Hs
		195770 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ASAP2_HUMAN (1-677): 4.54e-148: 465: 53.42
+	Hs
		63069 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		RHG42_HUMAN (21-405): 5.28e-83: 287: 16.26
+	Hs
		1356881 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ASAP1_HUMAN (1-679): 3.16e-134: 431: 47.89
+	Hs
		63070 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		RHG42_HUMAN (21-405): 5.28e-83: 287: 16.26
+	Hs
		802704 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ARAP1_HUMAN (222-585): 4.29e-52: 200: 20.89
+	Rn
		499164 PLCG1_RAT (8-302): 1.46e-26: 111: 15.72		AGAP2_RAT (357-645): 2.23e-79: 282: 30.41
+	Hs
		924812 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		CYH2_HUMAN (43-395): 6.34e-67: 231: 12.53
+	Hs
		924798 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ARAP1_HUMAN (222-585): 4.29e-52: 200: 20.89
+	Hs
		1262768 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ARAP3_HUMAN (346-586): 2.33e-55: 210: 28.74
+	Hs
		209145 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ARAP1_HUMAN (222-585): 4.29e-52: 200: 20.89
+	Hs
		924582 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ACAP1_HUMAN (675-788): 1.21e-10: 67.4: 7.63