Protein: SYSC
Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser) synthetase)

Gene: SYSC, SES1
Organism: Saccharomyces cerevisiae S288C
Interactions: 74
UniProt ID: P07284

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002181 - cytoplasmic translation
GO:0004828 - serine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

455581

PEX21
Peroxisomal protein PEX21

4

0

Small-scale

0.667

High

455579

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

455544

RAD53
Serine/threonine-protein kinase RAD53

2

0

High-throughput

0.569

High

455603

HRP1
Nuclear polyadenylated RNA-binding protein 4

2

0

High-throughput

0.563

High

455573

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.536

High

455585

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

455602

DUF1
DUB-associated factor 1

1

2

High-throughput

0.536

High

454364

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

455553

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

455568

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.513

High

455543

MCK1
Protein kinase MCK1

1

2

High-throughput

0.501

High

455546

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

455548

KCC4
Probable serine/threonine-protein kinase KCC4

1

2

High-throughput

0.501

High

455549

SSK22
Serine/threonine-protein kinase SSK22

1

1

High-throughput

0.501

High

455556

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

High-throughput

0.501

High

455563

HSL1
Probable serine/threonine-protein kinase HSL1

1

3

High-throughput

0.501

High

455580

IKS1
Probable serine/threonine-protein kinase IKS1

1

2

High-throughput

0.501

High

455586

KIN4
Serine/threonine-protein kinase KIN4

1

2

High-throughput

0.501

High

455587

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

1

High-throughput

0.501

High

455588

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.501

High

455593

HRK1
Serine/threonine-protein kinase HRK1

1

3

High-throughput

0.501

High

455565

DRE2
Fe-S cluster assembly protein DRE2

1

0

High-throughput

0.493

High

455597

CSN10
COP9 signalosome complex subunit 10

1

0

High-throughput

0.493

High

455591

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.489

High

455600

AIR2
Protein AIR2

1

1

High-throughput

0.489

High

437865

KAPC
cAMP-dependent protein kinase type 3

1

0

High-throughput

0.480

High

455539

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

455551

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.480

High

455564

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.480

High

365526

PGK
Phosphoglycerate kinase

1

2

High-throughput

0.479

High

367856

ENO2
Enolase 2

1

2

High-throughput

0.479

High

392026

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.479

High

434701

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

455541

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.479

High

455547

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

455550

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

455554

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

455555

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

455558

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

455560

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

455561

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

455569

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

455570

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

455571

DHH1
ATP-dependent RNA helicase DHH1

1

3

High-throughput

0.479

High

455572

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

455574

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

455578

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

455582

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

455583

HST2
NAD-dependent protein deacetylase HST2

1

2

High-throughput

0.479

High

455589

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

455598

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

455599

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

455545

SAN1
Protein SAN1

1

0

Small-scale

0.460

High

416342

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

439192

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

455542

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.458

High

455566

ADH5
Alcohol dehydrogenase 5

1

0

High-throughput

0.458

High

455590

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

455595

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

455601

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

455540

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

455559

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

455575

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

455562

CASP
Protein CASP

1

3

High-throughput

0.439

High

455552

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

455567

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

455592

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

455594

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

455596

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

444814

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.279

Low

455557

CDC3
Cell division control protein 3

1

0

High-throughput

0.251

Low

455576

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

455584

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

455577

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025