HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 352
+	Hs
		802738 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SH22A_HUMAN (17-212): 4.9e-39: 144: 29.35
+	Hs
		802685 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SHIP1_HUMAN (31-226): 5.5e-36: 140: 23.90
+	Hs
		522848 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		802558 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		802683 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		P55G_HUMAN (13-130): 1.15e-30: 122: 25.41
+	Hs
		433280 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		802882 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		SHIP1_HUMAN (31-226): 5.5e-36: 140: 23.90
+	Mm
		815098 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		SHIP1_MOUSE (31-225): 8.68e-36: 140: 22.06
+	Hs
		411981 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		802818 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		411580 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		796460 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20
+	Mm
		796508 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		ZAP70_MOUSE (33-129): 2.06e-16: 82.1: 32.00
+	Hs
		924777 Q96D37_HUMAN (11-189): 5.17e-47: 170: 28.21		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		548630 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		PLCG2_HUMAN (6-159): 1.15e-24: 107: 17.65
+	Hs
		548634 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		796524 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Mm
		796493 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		ZAP70_MOUSE (33-129): 2.06e-16: 82.1: 32.00
+	Hs
		548656 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Hs
		548655 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20