HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ARAP1 (Q96P48)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
Gene: ARAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	31980649, 33961781, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 1450
+	Hs
		924798 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ARAP1_HUMAN (1-1450): 0: 1074: 100.00
+	Hs
		209145 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ARAP1_HUMAN (1-1450): 0: 1074: 100.00
+	Hs
		1262768 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ARAP3_HUMAN (4-1430): 0: 788: 32.76
+	Hs
		64670 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		195788 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		64671 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		64654 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		64687 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Dm
		993184 GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43		Q0KHR5_DROME (624-1404): 8.84e-87: 314: 16.88
+	Hs
		195785 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Rn
		499164 PLCG1_RAT (8-302): 1.46e-26: 111: 15.72		AGAP2_RAT (277-760): 3.08e-80: 291: 17.25
+	Hs
		195791 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		924686 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		RHG12_HUMAN (595-1140): 4.27e-81: 288: 17.41
+	Hs
		64627 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		924608 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		Q1RLN5_HUMAN (617-1140): 1.42e-77: 276: 17.04
+	Hs
		200212 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SRGP3_HUMAN (623-1221): 8.56e-72: 264: 13.76
+	Hs
		195770 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		195795 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		208987 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		CHIN_HUMAN (845-1139): 1.19e-70: 247: 22.37
+	Hs
		924893 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		RHG35_HUMAN (970-1118): 2.63e-20: 100: 36.91