HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2, Ank_2~SH3_1, SH3_1~SH3_2, SH3_2~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding GO:0097110 - scaffold protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 1731
+	Hs
		802895 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		581050 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		924841 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		1115913 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		1078902 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		557787 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		802780 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		581080 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		924955 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Hs
		557831 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Rn
		1137278 CRKL_RAT (2-302): 9.86e-57: 186: 47.42		KDIS_RAT (166-567): 4.07e-53: 208: 15.84
+	Hs
		802917 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		KDIS_HUMAN (166-567): 9.38e-52: 204: 15.35
+	Hs
		924484 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		557660 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		209131 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		CSKI2_HUMAN (187-1345): 1.46e-34: 147: 14.44
+	Hs
		557753 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		CSKI2_HUMAN (187-1345): 1.46e-34: 147: 14.44
+	Hs
		1263386 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		CSKI2_HUMAN (187-1345): 1.46e-34: 147: 14.44
+	Hs
		1078859 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50