Protein: OTU2
OTU domain-containing protein 2

Gene: OTU2
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P38747

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

689435

RS7A
Small ribosomal subunit protein eS7A

3

2

Small-scale

0.746

High

149743

RS9A
Small ribosomal subunit protein uS4A

2

1

High-throughput

0.584

High

514622

RS18A
Small ribosomal subunit protein uS13A

2

1

High-throughput

0.584

High

778311

RS27A
Small ribosomal subunit protein eS27A

2

1

High-throughput

0.584

High

792026

GBLP
Small ribosomal subunit protein RACK1

2

3

High-throughput

0.584

High

796565

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

1

Small-scale

0.584

High

802150

RS20
Small ribosomal subunit protein uS10

2

1

High-throughput

0.584

High

803285

RIO1
Serine/threonine-protein kinase RIO1

2

1

High-throughput

0.584

High

435069

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.559

High

435943

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.559

High

674603

RS2
Small ribosomal subunit protein uS5

2

0

High-throughput

0.559

High

803266

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.553

High

721915

XPO1
Exportin-1

1

4

High-throughput

0.536

High

383684

RS17A
Small ribosomal subunit protein eS17A

2

1

High-throughput

0.533

High

455044

RS19A
Small ribosomal subunit protein eS19A

2

1

High-throughput

0.533

High

512990

RS8A
Small ribosomal subunit protein eS8A

2

1

High-throughput

0.533

High

747344

RSSA1
Small ribosomal subunit protein uS2A

2

2

High-throughput

0.533

High

753351

RS3A1
Small ribosomal subunit protein eS1A

2

1

High-throughput

0.533

High

441123

KAPA
cAMP-dependent protein kinase type 1

1

4

High-throughput

0.501

High

656455

KC11
Casein kinase I homolog 1

1

4

High-throughput

0.501

High

803255

AURK
Aurora kinase

1

9

High-throughput

0.501

High

803268

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.480

High

803274

ENT5
Epsin-5

1

0

Small-scale

0.480

High

632890

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

1

Small-scale

0.479

High

666448

DBP2
ATP-dependent RNA helicase DBP2

1

2

High-throughput

0.479

High

803258

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

803262

RIO2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.479

High

803269

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.479

High

803270

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

803271

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.479

High

803272

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

803279

YL419
Putative ATP-dependent RNA helicase YLR419W

1

4

High-throughput

0.479

High

512070

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

678236

BUD23
18S rRNA

1

0

High-throughput

0.458

High

688879

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

732060

SYKM
Lysine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

780896

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.458

High

803256

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

803267

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

803273

RLI1
Translation initiation factor RLI1

1

0

Small-scale

0.458

High

803280

TSR1
Ribosome biogenesis protein TSR1

1

0

High-throughput

0.458

High

803288

YN12B
Transposon Ty1-NL2 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

803281

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.457

High

523839

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

544753

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

741510

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

435562

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.437

High

455402

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.437

High

502644

RS25B
Small ribosomal subunit protein eS25B

1

1

High-throughput

0.437

High

502724

RS21A
Small ribosomal subunit protein eS21A

1

1

High-throughput

0.437

High

511791

RS24A
Small ribosomal subunit protein eS24A

1

1

High-throughput

0.437

High

570244

RS17B
Small ribosomal subunit protein eS17B

1

1

High-throughput

0.437

High

655450

RS3A2
Small ribosomal subunit protein eS1B

1

1

High-throughput

0.437

High

737716

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

Small-scale

0.437

High

799743

IF5
Eukaryotic translation initiation factor 5

1

1

Small-scale

0.437

High

802722

RS27B
Small ribosomal subunit protein eS27B

1

1

High-throughput

0.437

High

803259

RS26A
Small ribosomal subunit protein eS26A

1

1

High-throughput

0.437

High

803260

RS26B
Small ribosomal subunit protein eS26B

1

1

High-throughput

0.437

High

803263

RS29A
Small ribosomal subunit protein uS14A

1

1

High-throughput

0.437

High

803264

RS29B
Small ribosomal subunit protein uS14B

1

1

High-throughput

0.437

High

803265

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.437

High

803276

TMA64
Translation machinery-associated protein 64

1

1

High-throughput

0.437

High

803286

RS21B
Small ribosomal subunit protein eS21B

1

1

High-throughput

0.437

High

803287

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.437

High

803278

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

441890

RS14A
Small ribosomal subunit protein uS11A

2

0

High-throughput

0.305

High

512421

RS6A
Small ribosomal subunit protein eS6A

2

0

High-throughput

0.305

High

803284

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.251

Low

410110

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433621

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

438427

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.249

Low

503024

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

503488

RS28B
Small ribosomal subunit protein eS28B

1

0

High-throughput

0.249

Low

504193

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

514136

RS16B
Small ribosomal subunit protein uS9B

1

0

High-throughput

0.249

Low

624747

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

803257

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

803261

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

803275

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

803277

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

Small-scale

0.249

Low

803282

NAT5
N-alpha-acetyltransferase NAT5

1

0

High-throughput

0.249

Low

803283

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025