HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: TRI15 (Q9C019)
E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)
Gene: TRIM15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	25450970
Identification Methods	protein complementation assay, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 465
+	Hs
		802736 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		TRI39_HUMAN (7-464): 4.51e-144: 423: 30.39
+	Hs
		924879 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		TRI39_HUMAN (7-464): 4.51e-144: 423: 30.39
+	Mm
		1143604 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		TRI27_MOUSE (1-464): 6.05e-141: 415: 31.25
+	Hs
		275202 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		TRI68_HUMAN (1-464): 2.6e-132: 392: 27.77
+	Hs
		536781 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		TRI27_HUMAN (1-464): 6.32e-141: 415: 31.05
+	Hs
		584954 GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67		RO52_HUMAN (1-464): 3.3e-143: 419: 28.54
+	Hs
		557799 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		TRI39_HUMAN (7-464): 4.51e-144: 423: 30.39
+	Hs
		208986 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TRI27_HUMAN (1-464): 6.32e-141: 415: 31.05
+	Hs
		209157 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TRI15_HUMAN (1-465): 2.94e-140: 412: 100.00
+	Hs
		1078906 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		TRIM5_HUMAN (3-464): 7.5e-113: 343: 24.05
+	Hs
		209130 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TRI41_HUMAN (1-44): 6.43e-10: 63.3: 33.33