HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	31980649, 33961781, 19380743, 20534451, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0016477 - cell migration
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 1746
+	Hs
		802905 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		924867 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Mm
		1141136 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		PEAK1_MOUSE (1-1746): 0: 2159: 85.76
+	Hs
		209171 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		568579 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		580979 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		KPCE_HUMAN (1354-1719): 3.19e-92: 318: 13.98
+	Hs
		580944 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		682092 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Mm
		1123037 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		PRAG1_MOUSE (1-91): 5.76e-34: 145: 38.04
+	Hs
		802632 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46
+	Hs
		802648 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43
+	Hs
		802861 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46
+	Hs
		802866 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43
+	Hs
		883142 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		HUNK_HUMAN (1405-1659): 1.25e-44: 176: 20.61
+	Hs
		924654 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46
+	Hs
		924680 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PRAG1_HUMAN (1-91): 6.17e-28: 125: 40.43
+	Ce
		136804 VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80