HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DOCK5 (Q9H7D0)
Dedicator of cytokinesis protein 5
Gene: DOCK5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	27669437, 31980649, 33961781, 35044719, unassigned2173
Identification Methods	affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation, phage display
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1, DOCK_N~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration GO:1900026 - positive regulation of substrate adhesion-dependent cell spreading
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 1870
+	Hs
		802906 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOCK5_HUMAN (1-1870): 0: 1989: 100.00
+	Hs
		802596 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		802842 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		924868 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK5_HUMAN (1-1870): 0: 1989: 100.00
+	Mm
		1141146 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOCK1_MOUSE (1-1824): 0: 1945: 64.15
+	Hs
		802881 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Hs
		548738 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Hs
		924565 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		209053 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		557689 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		802655 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Dm
		1362940 CRK_DROME (5-302): 8.8e-52: 173: 43.14		Q9VCH4_DROME (1-1821): 0: 1698: 36.40
+	Hs
		924695 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Hs
		924698 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK4_HUMAN (4-1867): 0: 1688: 34.61
+	Hs
		557736 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Hs
		1078864 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		DOCK4_HUMAN (4-1867): 0: 1688: 34.61
+	Ce
		107035 CED2_CAEEL (4-293): 3.24e-36: 133: 27.80		G5EEN3_CAEEL (12-1712): 0: 1360: 26.82
+	Dm
		1228832 CRK_DROME (5-302): 8.8e-52: 173: 43.14		Q8MQW7_DROME (683-1821): 0: 1050: 36.60
+	Hs
		554292 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MUC1_HUMAN (1639-1843): 1.51e-14: 81.8: 8.17