HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ASAP1 (Q9ULH1)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Gene: ASAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.937

Property	Details
Experiments	31980649, 9819391, 33961781, 19380743, 17474147, unassigned2173
Identification Methods	affinity chromatography technology, pull down, peptide array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, PH~SH3_1, SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 1129
+	Hs
		802918 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		275240 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		581076 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		924943 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		1356881 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		195788 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		195785 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		802672 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ASAP3_HUMAN (21-913): 7.03e-177: 544: 44.27
+	Hs
		195791 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		802877 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		ASAP3_HUMAN (21-913): 7.03e-177: 544: 44.27
+	Hs
		195770 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ASAP2_HUMAN (21-967): 0: 647: 55.31
+	Hs
		924582 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ACAP1_HUMAN (45-690): 2.77e-153: 477: 21.01
+	Hs
		802704 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Rn
		499164 PLCG1_RAT (8-302): 1.46e-26: 111: 15.72		AGAP2_RAT (379-660): 5.08e-87: 308: 29.02
+	Hs
		924798 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Hs
		63069 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02
+	Hs
		209145 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Hs
		1262768 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		ARAP3_HUMAN (368-605): 4.78e-56: 215: 27.46
+	Hs
		209052 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		63070 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02