Protein: DRS1
ATP-dependent RNA helicase DRS1 (EC 3.6.4.13) (Deficiency of ribosomal subunits protein 1)

Gene: DRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 156
UniProt ID: P32892

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

746697

DBP10
ATP-dependent RNA helicase DBP10

5

18

High-throughput

0.924

High

746690

YTM1
Ribosome biogenesis protein YTM1

5

20

Small-scale

0.915

High

746672

ERB1
Ribosome biogenesis protein ERB1

4

15

High-throughput

0.903

High

746622

CIC1
Proteasome-interacting protein CIC1

4

5

High-throughput

0.886

High

746598

DRS1
ATP-dependent RNA helicase DRS1

3

16

High-throughput

0.834

High

746665

HAS1
ATP-dependent RNA helicase HAS1

3

17

High-throughput

0.827

High

633145

MAK11
Protein MAK11

2

20

Small-scale

0.754

High

673554

NLE1
Ribosome assembly protein 4

2

20

Small-scale

0.754

High

682221

SPB4
ATP-dependent rRNA helicase SPB4

2

19

High-throughput

0.754

High

746615

NOP4
Nucleolar protein 4

6

15

Small-scale

0.737

High

746647

NSA1
Ribosome biogenesis protein NSA1

7

1

Small-scale

0.736

High

746650

PESC
Pescadillo homolog

6

7

Small-scale

0.730

High

746628

NOC2
Nucleolar complex protein 2

6

2

Small-scale

0.723

High

746635

RLP7
Ribosome biogenesis protein RLP7

5

14

Small-scale

0.716

High

746614

RPF2
Ribosome biogenesis protein RPF2

5

3

Small-scale

0.709

High

746623

SSF1
Ribosome biogenesis protein SSF1

5

9

Small-scale

0.703

High

746639

LOC1
60S ribosomal subunit assembly/export protein LOC1

4

1

High-throughput

0.702

High

746698

IF6
Eukaryotic translation initiation factor 6

4

3

Small-scale

0.694

High

746636

NOP2
25S rRNA

4

10

Small-scale

0.691

High

746654

NOP15
Ribosome biogenesis protein 15

4

20

High-throughput

0.691

High

746695

MAK21
Ribosome biogenesis protein MAK21

4

14

High-throughput

0.680

High

746610

EBP2
rRNA-processing protein EBP2

3

5

High-throughput

0.646

High

746631

NSA2
Ribosome biogenesis protein NSA2

3

2

High-throughput

0.646

High

746683

NOP12
Nucleolar protein 12

3

20

High-throughput

0.646

High

746661

NOG1
Nucleolar GTP-binding protein 1

3

9

Small-scale

0.640

High

746657

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

2

3

High-throughput

0.619

High

448945

TOP2
DNA topoisomerase 2

1

2

High-throughput

0.618

High

746613

DBP7
ATP-dependent RNA helicase DBP7

1

16

High-throughput

0.618

High

746617

MAK5
ATP-dependent RNA helicase MAK5

1

16

High-throughput

0.618

High

746641

MTR4
ATP-dependent RNA helicase DOB1

1

17

Small-scale

0.618

High

746667

RRP17
Ribosomal RNA-processing protein 17

1

1

High-throughput

0.618

High

746668

DHR1
Probable ATP-dependent RNA helicase DHR1

1

16

High-throughput

0.618

High

746676

DBP9
ATP-dependent RNA helicase DBP9

1

16

High-throughput

0.618

High

746624

RPF1
Ribosome production factor 1

2

5

High-throughput

0.611

High

746653

NOP13
Nucleolar protein 13

2

18

High-throughput

0.611

High

746670

PUF6
Pumilio homology domain family member 6

2

7

High-throughput

0.611

High

746684

BRX1
Ribosome biogenesis protein BRX1

2

20

High-throughput

0.611

High

746608

RRP1
Ribosomal RNA-processing protein 1

2

9

Small-scale

0.584

High

746619

ENP1
Essential nuclear protein 1

2

7

High-throughput

0.584

High

746651

NOG2
Nucleolar GTP-binding protein 2

2

15

Small-scale

0.584

High

746691

NOP53
Ribosome biogenesis protein NOP53

2

7

High-throughput

0.584

High

523456

HSP71
Heat shock protein SSA1

2

15

High-throughput

0.571

High

746693

SSF2
Ribosome biogenesis protein SSF2

2

9

High-throughput

0.571

High

594279

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.553

High

644894

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

5

High-throughput

0.553

High

746616

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.553

High

746644

RS12
Small ribosomal subunit protein eS12

1

6

High-throughput

0.553

High

746659

KIN4
Serine/threonine-protein kinase KIN4

1

7

High-throughput

0.536

High

746680

NOP6
Nucleolar protein 6

1

2

High-throughput

0.536

High

746686

HRK1
Serine/threonine-protein kinase HRK1

1

7

High-throughput

0.536

High

364436

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.501

High

440834

KIN28
Serine/threonine-protein kinase KIN28

1

9

High-throughput

0.501

High

441079

KAPA
cAMP-dependent protein kinase type 1

1

12

High-throughput

0.501

High

574660

KSS1
Mitogen-activated protein kinase KSS1

1

7

High-throughput

0.501

High

585892

CSK21
Casein kinase II subunit alpha

1

14

High-throughput

0.501

High

602376

PHO85
Cyclin-dependent protein kinase PHO85

1

9

High-throughput

0.501

High

645900

DBF2
Cell cycle protein kinase DBF2

1

12

High-throughput

0.501

High

656407

KC11
Casein kinase I homolog 1

1

11

High-throughput

0.501

High

709333

HRR25
Casein kinase I homolog HRR25

1

5

High-throughput

0.501

High

738018

MKK1
MAP kinase kinase MKK1/SSP32

1

16

High-throughput

0.501

High

745267

ELM1
Serine/threonine-protein kinase ELM1

1

1

High-throughput

0.501

High

746601

SWE1
Mitosis inhibitor protein kinase SWE1

1

14

High-throughput

0.501

High

746607

HSL1
Probable serine/threonine-protein kinase HSL1

1

8

High-throughput

0.501

High

746620

RCK1
Serine/threonine-protein kinase RCK1

1

11

High-throughput

0.501

High

746626

AURK
Aurora kinase

1

14

High-throughput

0.501

High

746638

CAK1
Serine/threonine-protein kinase CAK1

1

18

High-throughput

0.501

High

746643

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

9

High-throughput

0.501

High

746646

ATG1
Serine/threonine-protein kinase ATG1

1

5

High-throughput

0.501

High

746662

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

16

High-throughput

0.501

High

746663

PKH3
Serine/threonine-protein kinase PKH3

1

16

High-throughput

0.501

High

746664

STE20
Serine/threonine-protein kinase STE20

1

10

High-throughput

0.501

High

746666

SKY1
Serine/threonine-protein kinase SKY1

1

20

High-throughput

0.501

High

746692

YP150
Putative serine/threonine-protein kinase YPL150W

1

5

High-throughput

0.501

High

746696

PKH2
Serine/threonine-protein kinase PKH2

1

17

High-throughput

0.501

High

542952

CDC24
Cell division control protein 24

1

3

High-throughput

0.489

High

746603

DOM34
Protein DOM34

1

1

High-throughput

0.489

High

732049

SYKM
Lysine--tRNA ligase, mitochondrial

1

2

Small-scale

0.481

High

746640

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.480

High

149667

RS9A
Small ribosomal subunit protein uS4A

1

10

High-throughput

0.479

High

410022

RL25
Large ribosomal subunit protein uL23

1

8

High-throughput

0.479

High

432530

RL7A
Large ribosomal subunit protein uL30A

1

14

High-throughput

0.479

High

433540

RL26A
Large ribosomal subunit protein uL24A

1

9

High-throughput

0.479

High

434957

RS3
Small ribosomal subunit protein uS3

1

9

High-throughput

0.479

High

435864

RS13
Small ribosomal subunit protein uS15

1

8

High-throughput

0.479

High

441804

RS14A
Small ribosomal subunit protein uS11A

1

10

High-throughput

0.479

High

454959

RS19A
Small ribosomal subunit protein eS19A

1

11

High-throughput

0.479

High

512340

RS6A
Small ribosomal subunit protein eS6A

1

10

High-throughput

0.479

High

534090

MAK16
Protein MAK16

1

4

High-throughput

0.479

High

670510

SIS1
Protein SIS1

1

7

High-throughput

0.479

High

674511

RS2
Small ribosomal subunit protein uS5

1

12

High-throughput

0.479

High

677179

SPB1
27S pre-rRNA

1

10

High-throughput

0.479

High

677328

KRR1
KRR1 small subunit processome component

1

8

High-throughput

0.479

High

688986

RL16A
Large ribosomal subunit protein uL13A

1

10

High-throughput

0.479

High

689350

RS7A
Small ribosomal subunit protein eS7A

1

6

High-throughput

0.479

High

746602

MRT4
Ribosome assembly factor MRT4

1

8

High-throughput

0.479

High

746604

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

3

High-throughput

0.479

High

746606

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

Small-scale

0.479

High

746609

RS27A
Small ribosomal subunit protein eS27A

1

7

High-throughput

0.479

High

746611

RRP14
Ribosomal RNA-processing protein 14

1

1

High-throughput

0.479

High

746612

RL14A
Large ribosomal subunit protein eL14A

1

6

High-throughput

0.479

High

746618

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

746625

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

6

High-throughput

0.479

High

746629

NOP16
Nucleolar protein 16

1

1

High-throughput

0.479

High

746630

NUG1
Nuclear GTP-binding protein NUG1

1

15

High-throughput

0.479

High

746632

ATAD2
ATPase histone chaperone YTA7

1

12

High-throughput

0.479

High

746637

UTP10
U3 small nucleolar RNA-associated protein 10

1

5

High-throughput

0.479

High

746645

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.479

High

746652

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

20

High-throughput

0.479

High

746655

RCM1
25S rRNA

1

10

High-throughput

0.479

High

746658

RS15
Small ribosomal subunit protein uS19

1

7

High-throughput

0.479

High

746660

XRN2
5'-3' exoribonuclease 2

1

4

High-throughput

0.479

High

746671

UTP14
U3 small nucleolar RNA-associated protein 14

1

4

High-throughput

0.479

High

746673

RRP5
rRNA biogenesis protein RRP5

1

17

High-throughput

0.479

High

746675

FKBP4
FK506-binding protein 4

1

6

High-throughput

0.479

High

746677

RRP15
Ribosomal RNA-processing protein 15

1

1

High-throughput

0.479

High

746678

NOC4
Nucleolar complex protein 4

1

14

High-throughput

0.479

High

746681

NOC3
Nucleolar complex-associated protein 3

1

11

High-throughput

0.479

High

746682

RLP24
Ribosome biogenesis protein RLP24

1

8

High-throughput

0.479

High

746687

RS10A
Small ribosomal subunit protein eS10A

1

8

High-throughput

0.479

High

746688

RRS1
Regulator of ribosome biosynthesis

1

4

High-throughput

0.479

High

746689

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

746694

YRA1
RNA annealing protein YRA1

1

12

High-throughput

0.479

High

477535

MYO1
Myosin-1

1

0

Small-scale

0.458

High

746642

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

734512

MSB2
Signaling mucin MSB2

1

5

Small-scale

0.457

High

510335

HSP77
Import motor subunit, mitochondrial

1

11

High-throughput

0.445

High

526261

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

544283

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

741246

HSP7F
Heat shock protein homolog SSE1

1

18

High-throughput

0.445

High

381038

H2B1
Histone H2B.1

1

8

High-throughput

0.437

High

381467

H2B2
Histone H2B.2

1

8

High-throughput

0.437

High

381984

H4
Histone H4

1

9

High-throughput

0.437

High

383600

RS17A
Small ribosomal subunit protein eS17A

1

6

High-throughput

0.437

High

419669

H2A2
Histone H2A.2

1

7

High-throughput

0.437

High

436358

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

5

High-throughput

0.437

High

502941

RS22A
Small ribosomal subunit protein uS8A

1

9

High-throughput

0.437

High

504122

RL31A
Large ribosomal subunit protein eL31A

1

13

High-throughput

0.437

High

512906

RS8A
Small ribosomal subunit protein eS8A

1

8

High-throughput

0.437

High

514542

RS18A
Small ribosomal subunit protein uS13A

1

8

High-throughput

0.437

High

706613

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.437

High

734906

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

4

High-throughput

0.437

High

746599

RSSA1
Small ribosomal subunit protein uS2A

1

15

High-throughput

0.437

High

746600

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

746605

RS3A1
Small ribosomal subunit protein eS1A

1

8

High-throughput

0.437

High

746621

RS20
Small ribosomal subunit protein uS10

1

11

High-throughput

0.437

High

746627

LAA1
AP-1 accessory protein LAA1

1

6

High-throughput

0.437

High

746633

ULP2
Ubiquitin-like-specific protease 2

1

6

High-throughput

0.437

High

746634

DSN1
Kinetochore-associated protein DSN1

1

5

High-throughput

0.437

High

746649

EIF2A
Eukaryotic translation initiation factor 2A

1

6

High-throughput

0.437

High

746656

H3
Histone H3

1

19

High-throughput

0.437

High

746669

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.437

High

746674

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.437

High

746679

VAM6
Vacuolar morphogenesis protein 6

1

5

High-throughput

0.437

High

746685

SGO1
Shugoshin

1

4

High-throughput

0.437

High

746648

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025