HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 676
+	Hs
		802920 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		275242 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		581081 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		562669 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		802588 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		802837 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		548703 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		69824 B1AT92_MOUSE (135-297): 3.98e-27: 106: 15.39		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Mm
		1114082 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		1246955 Q8R5B8_MOUSE (2-114): 3.18e-43: 145: 65.49		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		1035413 VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		275195 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		855792 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		581001 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		562645 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		1143296 PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Mm
		1141170 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		802856 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		1153260 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		802907 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46