HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: ELMO2 (Q96JJ3)
Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A)
Gene: ELMO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030971 - receptor tyrosine kinase binding GO:0060326 - cell chemotaxis
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 720
+	Hs
		802850 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		Q5JVZ5_HUMAN (1-720): 0: 1047: 99.72
+	Hs
		802880 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		802699 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		802682 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		802691 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Hs
		924793 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Mm
		1141144 GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32		ELMO2_MOUSE (1-720): 0: 1042: 97.13
+	Hs
		924774 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Ce
		1248330 CED2_CAEEL (1-298): 3.79e-38: 138: 27.10		CED12_CAEEL (27-713): 0: 673: 21.49