HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	9660791, 11334882, 10871282
Identification Methods	affinity chromatography technology, unspecified method, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 676
+	Hs
		802781 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		275242 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		581081 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		802837 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		562669 PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Hs
		1040322 GRAP_HUMAN (126-294): 1.63e-24: 100: 19.07		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Mm
		292691 GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Hs
		802588 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		1246955 Q8R5B8_MOUSE (1-98): 1.74e-50: 163: 97.96		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		855792 VAV2_HUMAN (14-180): 4.46e-40: 150: 19.80		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		275195 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		292690 GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		581001 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		562645 PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		1143296 PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		557681 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		802856 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		PKHA7_HUMAN (6-456): 1.7e-80: 278: 14.62
+	Hs
		802907 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		PKHA1_HUMAN (3-163): 2.62e-36: 142: 23.46
+	Dm
		993221 GRAP_DROME (126-293): 1.68e-23: 97.6: 17.79		DOS_DROME (8-218): 1.26e-36: 149: 30.22
+	Dm
		993229 GRAP_DROME (126-293): 1.68e-23: 97.6: 17.79		X2JFU3_DROME (9-119): 3.8e-24: 104: 24.32