HitPredict

Interactor 1: BAG6 (P46379)
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)
Gene: BAG6

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	35543156, 36045679, 32877691, 21903422
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CARD_2~ubiquitin
Common GO terms	GO:0060090 - molecular adaptor activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1132 Hs			1 540
+	Hs
		803611 BAG6_HUMAN (1-1132): 0: 597: 100.00		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Hs
		1190122 UBQL2_HUMAN (13-587): 2.27e-26: 117: 14.71		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		867119 SC24C_HUMAN (380-696): 1.27e-39: 162: 24.18		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Hs
		924336 RL40_HUMAN (17-87): 9.53e-28: 111: 34.72		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Hs
		554259 MUC1_HUMAN (122-783): 1.91e-30: 132: 11.94		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Mm
		924239 RS27A_MOUSE (17-87): 2.18e-27: 111: 34.72		HUWE1_MOUSE (108-539): 1.87e-18: 91.8: 13.89
+	Hs
		867142 UBQL2_HUMAN (13-587): 2.27e-26: 117: 14.71		SC24C_HUMAN (116-429): 9.64e-11: 66.7: 15.43
+	Hs
		1057015 UBQL2_HUMAN (13-587): 2.27e-26: 117: 14.71		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		1192147 CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Mm
		1351630 PCLO_MOUSE (90-802): 1.36e-18: 94.4: 10.64		PCLO_MOUSE (74-489): 7.72e-09: 61: 12.14
+	Dm
		113976 M9PB30_DROME (9-480): 2.03e-14: 80.9: 11.20		M9PB30_DROME (46-383): 2.44e-09: 62.5: 12.43
+	Hs
		1172508 CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25		Q6ZTM8_HUMAN (34-430): 4.01e-11: 67.5: 12.94
+	Hs
		1056910 CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		1300971 CHD7_HUMAN (52-409): 9.99e-10: 65.5: 8.64		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Hs
		1170076 CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25		SRCAP_HUMAN (88-342): 3.17e-09: 62.1: 16.86