Protein: LCF1
Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Fatty acid activator 1) (Fatty acyl-CoA synthetase) (ACS) (FACS) (Long-chain acyl-CoA synthetase 1)

Gene: LCF1, FAA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P30624

Gene Ontology (top 5):
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

721101

FAT1
Very long-chain fatty acid transport protein

1

5

Small-scale

0.713

High

721108

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

645886

DBF2
Cell cycle protein kinase DBF2

1

3

High-throughput

0.536

High

721099

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.515

High

678777

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.513

High

575312

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.489

High

633447

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.489

High

721100

IMB2
Importin subunit beta-2

1

1

High-throughput

0.489

High

721106

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

392370

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

510273

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.479

High

514507

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

578994

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

624722

PMA2
Plasma membrane ATPase 2

1

2

High-throughput

0.479

High

677870

ADY2
Accumulation of dyads protein 2

1

1

High-throughput

0.479

High

679457

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

721092

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

721103

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

721107

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

721111

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.479

High

721116

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

721117

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

721094

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

721096

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

721118

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

721119

BSC2
Bypass of stop codon protein 2

1

0

Small-scale

0.458

High

523290

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

721105

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

430799

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.437

High

434901

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

558622

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

670428

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

706421

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

721093

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

721098

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

721104

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

721110

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

721112

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

721114

H3
Histone H3

1

3

High-throughput

0.437

High

721115

MDM1
Structural protein MDM1

1

1

Small-scale

0.437

High

721120

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

721095

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

721113

NM111
Pro-apoptotic serine protease NMA111

1

0

Small-scale

0.288

High

721109

JSN1
Protein JSN1

1

0

High-throughput

0.282

High

445320

CDC31
Cell division control protein 31

1

0

Small-scale

0.249

Low

721121

LAS17
Proline-rich protein LAS17

1

0

Small-scale

0.249

Low

721097

ERT1
Transcription activator of gluconeogenesis ERT1

1

0

High-throughput

0.238

Low

721102

YBR4
Putative uncharacterized membrane protein YBR064W

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025