HitPredict

Interactor 1: NSF (P46459)
Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)
Gene: NSF

Interactor 2: STX5 (Q13190)
Syntaxin-5
Gene: STX5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 20562859
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000149 - SNARE binding GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0045732 - positive regulation of protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 744 Hs			1 355
+	Mm
		192843 NSF_MOUSE (1-744): 0: 574: 98.12		STX1A_MOUSE (58-351): 1.71e-69: 221: 19.80
+	Hs
		699248 NSF_HUMAN (1-744): 0: 572: 100.00		STX2_HUMAN (58-354): 3.39e-67: 214: 18.27
+	Hs
		152139 NSF_HUMAN (1-744): 0: 572: 100.00		STX16_HUMAN (59-335): 2.37e-54: 183: 17.86
+	Hs
		803902 NSF_HUMAN (1-744): 0: 572: 100.00		STX4_HUMAN (58-354): 9.15e-54: 180: 17.22
+	Hs
		803907 NSF_HUMAN (1-744): 0: 572: 100.00		STX3_HUMAN (58-335): 8.33e-54: 180: 17.99
+	At
		870960 CD48A_ARATH (7-744): 1.44e-177: 530: 22.88		SYP31_ARATH (55-355): 6.21e-61: 200: 29.17
+	Dm
		804036 NSF1_DROME (6-741): 5.33e-169: 505: 62.47		STX1A_DROME (58-355): 4.82e-66: 212: 16.89
+	Dm
		870073 NSF2_DROME (5-742): 6.55e-166: 498: 63.21		STX1A_DROME (58-355): 4.82e-66: 212: 16.89
+	Dm
		870072 NSF2_DROME (5-742): 6.55e-166: 498: 63.21		STX5_DROME (55-339): 9.2e-64: 211: 53.74
+	At
		1338387 NSF_ARATH (1-730): 1.09e-145: 445: 42.90		SYP32_ARATH (48-355): 3.79e-67: 216: 34.58
+	Hs
		803944 NSF_HUMAN (1-744): 0: 572: 100.00		STX12_HUMAN (139-337): 1.24e-11: 66.3: 18.10
+	Hs
		178427 NSF_HUMAN (1-744): 0: 572: 100.00		STX7_HUMAN (133-334): 6.12e-09: 58.2: 17.70
+	At
		1340775 NSF_ARATH (1-730): 1.09e-145: 445: 42.90		SYP43_ARATH (64-354): 5.78e-52: 177: 15.83
+	Sc
		578556 SEC18_YEAST (4-721): 5.88e-146: 447: 44.22		SED5_YEAST (55-335): 7.71e-49: 169: 29.50
+	At
		955686 NSF_ARATH (1-730): 1.09e-145: 445: 42.90		SYP22_ARATH (77-342): 4.65e-48: 164: 13.91
+	Dd
		1122136 NSF_DICDI (5-724): 4.29e-146: 446: 44.20		STX7A_DICDI (86-354): 1.13e-40: 147: 21.43
+	Zm
		21303 A0A1D6KUI9_MAIZE (13-483): 4.71e-74: 258: 23.86		A0A1D6HSW4_MAIZE (61-338): 1.34e-50: 175: 15.84