HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	21398698
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation GO:0043235 - receptor complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 913
+	Hs
		132256 DLL1_HUMAN (31-226): 1.8e-23: 110: 37.37		DDR1_HUMAN (1-913): 0: 911: 100.00
+	Hs
		385709 NOTC3_HUMAN (1-2014): 0: 679: 27.54		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		507954 ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		507971 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		507831 ANK1_HUMAN (1963-2550): 1.92e-90: 331: 12.75		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		384666 ANK2_HUMAN (1662-2151): 4.82e-101: 367: 16.67		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		1021409 ANK3_HUMAN (1572-2114): 5.09e-98: 358: 17.60		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		257545 ANR17_HUMAN (1919-2553): 8.85e-80: 297: 13.87		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		385170 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		607947 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		980386 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		411321 FBN2_HUMAN (573-1697): 5.09e-30: 133: 15.09		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		980385 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		968293 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ROR1_HUMAN (604-902): 1.59e-55: 209: 37.79
+	Dm
		422748 NOTCH_DROME (1984-2545): 4.18e-12: 74.6: 12.78		Q0KIF4_DROME (616-901): 6.41e-50: 193: 38.33
+	Hs
		968361 NOTC2_HUMAN (2053-2553): 6.4e-09: 64.2: 9.77		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26