Protein: FIS1
Mitochondrial fission 1 protein (Mitochondrial division protein 2)

Gene: FIS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: P40515

Gene Ontology (top 5):
GO:0000266 - mitochondrial fission
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005777 - peroxisome
GO:0005778 - peroxisomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

825798

MDV1
Mitochondrial division protein 1

10

1

Small-scale

0.983

High

781879

CAF4
CCR4-associated factor 4

4

1

Small-scale

0.916

High

825794

FIS1
Mitochondrial fission 1 protein

3

2

Small-scale

0.843

High

825810

DNM1
Dynamin-related protein DNM1

3

3

Small-scale

0.646

High

677285

PEX34
Peroxisomal membrane protein PEX34

2

0

Small-scale

0.570

High

825826

ATG11
Autophagy-related protein 11

2

0

Small-scale

0.569

High

579534

HSC82
ATP-dependent molecular chaperone HSC82

2

0

Small-scale

0.559

High

825816

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

1

1

Small-scale

0.536

High

825807

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

Small-scale

0.529

High

825814

PEX19
Peroxisomal membrane protein import receptor PEX19

1

1

Small-scale

0.501

High

359019

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

Small-scale

0.479

High

359258

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

Small-scale

0.479

High

509590

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

526886

HSP72
Heat shock protein SSA2

1

2

Small-scale

0.479

High

679772

CDC48
Cell division control protein 48

1

2

Small-scale

0.479

High

779416

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

Small-scale

0.479

High

668921

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

High-throughput

0.460

High

365638

PGK
Phosphoglycerate kinase

1

0

Small-scale

0.458

High

394634

EF1A
Elongation factor 1-alpha

1

0

Small-scale

0.458

High

417118

VDAC1
Non-selective voltage-gated ion channel 1

1

0

Small-scale

0.458

High

510559

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.458

High

555098

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.458

High

572602

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.458

High

599035

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

Small-scale

0.458

High

619364

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

Small-scale

0.458

High

626768

HSP60
Heat shock protein 60, mitochondrial

1

0

Small-scale

0.458

High

738100

MYO4
Myosin-4

1

0

Small-scale

0.458

High

746862

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

781399

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

790207

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

Small-scale

0.458

High

802947

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

Small-scale

0.458

High

816080

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

Small-scale

0.458

High

818612

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

825797

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

825804

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

825806

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

Small-scale

0.458

High

825808

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

Small-scale

0.458

High

825809

ERG13
Hydroxymethylglutaryl-CoA synthase

1

0

Small-scale

0.458

High

825812

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

825817

HOSM
Homocitrate synthase, mitochondrial

1

0

Small-scale

0.458

High

825822

PEX11
Peroxisomal membrane protein PMP27

1

0

Small-scale

0.458

High

825827

BOL1
BolA-like protein 1

1

0

Small-scale

0.458

High

433225

RL17A
Large ribosomal subunit protein uL22A

1

1

Small-scale

0.437

High

481645

HSP73
Heat shock protein SSA3

1

2

Small-scale

0.437

High

524183

HSP71
Heat shock protein SSA1

1

2

Small-scale

0.437

High

545154

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

Small-scale

0.437

High

575465

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

Small-scale

0.437

High

585630

STI1
Heat shock protein STI1

1

2

Small-scale

0.437

High

592299

VATB
V-type proton ATPase subunit B

1

1

Small-scale

0.437

High

603490

VATA
V-type proton ATPase catalytic subunit A

1

2

Small-scale

0.437

High

671369

PHO84
Inorganic phosphate transporter PHO84

1

2

Small-scale

0.437

High

741730

HSP7F
Heat shock protein homolog SSE1

1

3

Small-scale

0.437

High

804219

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

Small-scale

0.437

High

825803

ASNS2
Asparagine synthetase [glutamine-hydrolyzing] 2

1

1

Small-scale

0.437

High

825821

NOP56
Nucleolar protein 56

1

1

Small-scale

0.437

High

825824

NOP58
Nucleolar protein 58

1

1

Small-scale

0.437

High

818953

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.407

High

814182

SEC72
Translocation protein SEC72

1

0

High-throughput

0.282

High

726152

2AAA
Protein phosphatase PP2A regulatory subunit A

1

0

High-throughput

0.265

Low

825800

JSN1
Protein JSN1

1

0

High-throughput

0.265

Low

825818

GET3
ATPase GET3

1

0

High-throughput

0.265

Low

692371

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.261

Low

782016

PET10
Protein PET10

1

0

High-throughput

0.251

Low

150111

YH11B
Transposon Ty1-H Gag-Pol polyprotein

1

0

Small-scale

0.249

Low

365070

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.249

Low

386739

TBB
Tubulin beta chain

1

0

Small-scale

0.249

Low

399371

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

0

Small-scale

0.249

Low

403539

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.249

Low

416247

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

432335

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

Small-scale

0.249

Low

434590

RL22A
Large ribosomal subunit protein eL22A

1

0

Small-scale

0.249

Low

438448

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.249

Low

438819

CYSD
Homocysteine/cysteine synthase

1

0

Small-scale

0.249

Low

452513

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

Small-scale

0.249

Low

512091

RS4A
Small ribosomal subunit protein eS4A

1

0

Small-scale

0.249

Low

513508

RL1A
Large ribosomal subunit protein uL1A

1

0

Small-scale

0.249

Low

515411

HMRA1
Silenced mating-type protein A1

1

0

Small-scale

0.249

Low

518313

IF4A
ATP-dependent RNA helicase eIF4A

1

0

Small-scale

0.249

Low

582477

SEC23
Protein transport protein SEC23

1

0

Small-scale

0.249

Low

597164

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.249

Low

597481

EF3A
Elongation factor 3A

1

0

Small-scale

0.249

Low

621376

METK2
S-adenosylmethionine synthase 2

1

0

Small-scale

0.249

Low

631942

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.249

Low

636590

PSA7
Probable proteasome subunit alpha type-7

1

0

Small-scale

0.249

Low

655579

TKT1
Transketolase 1

1

0

Small-scale

0.249

Low

747410

RSSA1
Small ribosomal subunit protein uS2A

1

0

Small-scale

0.249

Low

748427

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

793221

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

Small-scale

0.249

Low

805859

ARO9
Aromatic amino acid aminotransferase 2

1

0

Small-scale

0.249

Low

807087

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

Small-scale

0.249

Low

815089

SS120
Protein SSP120

1

0

Small-scale

0.249

Low

822403

PRS4
26S proteasome regulatory subunit 4 homolog

1

0

Small-scale

0.249

Low

823608

TCPE
T-complex protein 1 subunit epsilon

1

0

Small-scale

0.249

Low

825795

MKT1
Post-transcriptional regulator MKT1

1

0

Small-scale

0.249

Low

825796

TDA10
Probable ATP-dependent kinase TDA10

1

0

Small-scale

0.249

Low

825799

TCPQ
T-complex protein 1 subunit theta

1

0

Small-scale

0.249

Low

825801

VPS70
Vacuolar protein sorting-associated protein 70

1

0

Small-scale

0.249

Low

825802

RS12
Small ribosomal subunit protein eS12

1

0

Small-scale

0.249

Low

825805

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.249

Low

825811

NOG1
Nucleolar GTP-binding protein 1

1

0

Small-scale

0.249

Low

825815

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

825819

AHC1
Protein AHC1

1

0

Small-scale

0.249

Low

825820

YPR1
Aldehyde reductase YPR1

1

0

Small-scale

0.249

Low

825823

RUVB2
RuvB-like protein 2

1

0

Small-scale

0.249

Low

825825

NOT5
General negative regulator of transcription subunit 5

1

0

Small-scale

0.249

Low

825813

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025