HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: DLK2 (Q6UY11)
Protein delta homolog 2 (DLK-2) (Epidermal growth factor-like protein 9) (EGF-like protein 9)
Gene: DLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~EGF, EGF~EGF_CA
Common GO terms	GO:0005112 - Notch binding GO:0005509 - calcium ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 383
+	Hs
		804213 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		NOTC2_HUMAN (98-263): 4.59e-26: 112: 28.99
+	Hs
		804379 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		JAG2_HUMAN (47-383): 1e-22: 102: 21.04
+	Hs
		804372 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		NOTC3_HUMAN (46-255): 3.83e-14: 76.3: 31.65
+	Hs
		132252 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		DLL1_HUMAN (129-383): 4.64e-12: 69.3: 16.29
+	Hs
		804198 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		JAG1_HUMAN (129-383): 1.96e-11: 67.8: 13.31
+	Hs
		804163 NOTC1_HUMAN (20-2555): 0: 1387: 100.00		NOTC1_HUMAN (3-290): 1.05e-09: 62.4: 19.21
+	Mm
		966325 NOTC1_MOUSE (24-2555): 0: 1363: 90.53		DLL1_MOUSE (153-382): 6.99e-10: 62.8: 12.99
+	Hs
		1166910 NOTC3_HUMAN (1-2014): 0: 679: 27.54		DLK2_HUMAN (1-383): 5.01e-57: 192: 100.00
+	Hs
		980576 NOTC3_HUMAN (1-2014): 0: 679: 27.54		NOTC2_HUMAN (98-263): 4.59e-26: 112: 28.99
+	Hs
		1357251 NOTC3_HUMAN (1-2014): 0: 679: 27.54		JAG2_HUMAN (47-383): 1e-22: 102: 21.04
+	Hs
		1357250 NOTC3_HUMAN (1-2014): 0: 679: 27.54		NOTC3_HUMAN (46-255): 3.83e-14: 76.3: 31.65
+	Hs
		132268 NOTC3_HUMAN (1-2014): 0: 679: 27.54		DLL1_HUMAN (129-383): 4.64e-12: 69.3: 16.29
+	Hs
		944134 NOTC3_HUMAN (1-2014): 0: 679: 27.54		JAG1_HUMAN (129-383): 1.96e-11: 67.8: 13.31
+	Dm
		65546 A8JNM5_DROME (1677-2536): 7.87e-130: 462: 14.56		NOTCH_DROME (8-254): 4.99e-15: 78.9: 19.93
+	Dm
		246781 Q0KIE7_DROME (1783-2507): 6.09e-116: 408: 13.99		TENM_DROME (211-368): 1.91e-25: 110: 12.42
+	Hs
		980449 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		NOTC2_HUMAN (98-263): 4.59e-26: 112: 28.99
+	Hs
		1237561 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		NOTC3_HUMAN (46-255): 3.83e-14: 76.3: 31.65
+	Hs
		804293 ANR44_HUMAN (1554-2093): 7.06e-68: 252: 15.72		NOTC1_HUMAN (3-290): 1.05e-09: 62.4: 19.21
+	Dm
		90684 E1JHA6_DROME (6-297): 5.95e-51: 202: 33.22		NOTCH_DROME (8-254): 4.99e-15: 78.9: 19.93