Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1
Interactor 2: MAML1 (Q92585)
Mastermind-like protein 1 (Mam-1)
Gene: MAML1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.982 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17573339, 11101851, 22100894, 23022380, 30975888, 12370315, 20118921, 21820430, 11997524, 11390662, 18427106, 19907488 |
| Identification Methods | pull down, affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ank_2~MamL-1 |
| Common GO terms | GO:0002193 - MAML1-RBP-Jkappa- ICN1 complex GO:0003162 - atrioventricular node development GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 3 others more... |
| Homologous interactions | 13 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
