HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: MBD1 (Q9UIS9)
Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)
Gene: MBD1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006366 - transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 605
+	Hs
		1355890 NOTC3_HUMAN (1-2014): 0: 679: 27.54		MBD1_HUMAN (1-605): 0: 886: 100.00
+	Hs
		1355891 JAG2_HUMAN (1096-1581): 9.02e-42: 171: 22.92		MBD1_HUMAN (1-605): 0: 886: 100.00
+	Hs
		254238 MEGF6_HUMAN (21-573): 2.13e-35: 151: 24.92		MBD1_HUMAN (1-605): 0: 886: 100.00
+	Hs
		624338 TENA_HUMAN (1356-1565): 3.2e-18: 94.5: 20.94		MBD1_HUMAN (1-605): 0: 886: 100.00