HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: AMOL1 (Q8IY63)
Angiomotin-like protein 1
Gene: AMOTL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	33961781, 16055720
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 956
+	Hs
		808328 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12
+	Hs
		808151 NEDD4_HUMAN (1-1319): 0: 1956: 100.00		AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18
+	Hs
		1222263 NED4L_HUMAN (517-1319): 0: 934: 62.26		AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00
+	Hs
		1119034 NED4L_HUMAN (517-1319): 0: 934: 62.26		AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18
+	Hs
		1222267 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00
+	Hs
		724896 HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32		MYH9_HUMAN (226-951): 4.21e-24: 111: 9.29
+	Hs
		125569 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00
+	Hs
		1222275 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		AMOL1_HUMAN (1-956): 6.37e-156: 486: 100.00
+	Hs
		1327936 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12
+	Hs
		1119052 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18
+	Hs
		125805 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12
+	Hs
		125503 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18
+	Hs
		1119026 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18
+	Hs
		1350508 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		AMOL2_HUMAN (92-914): 4.21e-45: 177: 40.12
+	Hs
		1119083 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		AMOT_HUMAN (87-890): 1.03e-41: 168: 40.18
+	Hs
		1078893 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		ITSN1_HUMAN (608-950): 3e-09: 63.5: 11.36
+	Hs
		1035209 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		ROCK1_HUMAN (418-836): 1.93e-14: 80.1: 10.94
+	Hs
		149380 HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83		CTRO_HUMAN (238-841): 1.53e-21: 103: 12.00
+	Hs
		551845 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		DESP_HUMAN (417-798): 5.65e-11: 69.3: 15.63
+	Hs
		1336100 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		DAPLE_HUMAN (438-697): 6.07e-09: 62.6: 25.98