HitPredict

Interactor 1: NEDD4 (P46935)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: SCN8A (Q9WTU3)
Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
Gene: SCN8A

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006814 - sodium ion transport GO:0016020 - membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 887 Mm			1 1978
+	Mm
		69867 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCN2A_MOUSE (1-1977): 0: 1971: 72.90
+	Mm
		808358 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCN9A_MOUSE (4-1972): 0: 1915: 68.43
+	Hs
		808322 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCN8A_HUMAN (1-1978): 0: 2045: 98.23
+	Mm
		808363 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCNAA_MOUSE (6-1975): 0: 1785: 53.16
+	Mm
		69865 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCN2A_MOUSE (1-1977): 0: 1971: 72.90
+	Hs
		723839 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCN1A_HUMAN (1-1966): 0: 1908: 72.98
+	Hs
		1079738 SMUF2_HUMAN (79-883): 0: 678: 34.20		SCN9A_HUMAN (4-1977): 0: 1924: 69.41
+	Hs
		1055040 NED4L_HUMAN (70-887): 0: 777: 55.91		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		723851 SMUF2_HUMAN (79-883): 0: 678: 34.20		SCN1A_HUMAN (1-1966): 0: 1908: 72.98
+	Mm
		93274 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCN9A_MOUSE (4-1972): 0: 1915: 68.43
+	Hs
		808128 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		1055045 SMUF2_HUMAN (79-883): 0: 678: 34.20		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		125457 WWP2_HUMAN (75-884): 0: 675: 33.18		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		808340 NEDD4_HUMAN (157-887): 0: 724: 78.95		SCNAA_HUMAN (6-1973): 0: 1738: 53.71
+	Mm
		93276 E9PXB7_MOUSE (172-887): 0: 665: 56.84		SCNAA_MOUSE (6-1975): 0: 1785: 53.16
+	Mm
		808349 NEDD4_MOUSE (1-887): 0: 935: 100.00		Q3UF73_MOUSE (1-205): 2.02e-95: 308: 72.68
+	Mm
		808378 NEDD4_MOUSE (1-887): 0: 935: 100.00		SCN5A_MOUSE (343-654): 1.19e-13: 79.2: 11.98
+	Mm
		93270 E9PXB7_MOUSE (172-887): 0: 665: 56.84		Q3UF73_MOUSE (1-205): 2.02e-95: 308: 72.68
+	Hs
		1047217 NED4L_HUMAN (70-887): 0: 777: 55.91		CAC1C_HUMAN (20-336): 1.49e-15: 85.3: 16.32
+	Hs
		125445 WWP2_HUMAN (75-884): 0: 675: 33.18		CAC1C_HUMAN (20-336): 1.49e-15: 85.3: 16.32