HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	38280479, 30126976
Identification Methods	proximity labelling technology, p8 filamentous phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005911 - cell-cell junction GO:0030054 - cell junction GO:0030859 - polarized epithelial cell differentiation GO:0042060 - wound healing
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 1630
+	Hs
		1050053 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Mm
		1143429 NED4L_MOUSE (4-504): 5.54e-115: 364: 19.73		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		93273 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		280032 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		1271021 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Mm
		93267 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		DLG3_MOUSE (724-947): 3.57e-19: 96.3: 31.23
+	Mm
		808344 NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98		DLG3_MOUSE (724-947): 3.57e-19: 96.3: 31.23
+	Hs
		808565 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		1301441 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		808867 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Mm
		1143518 MAGI3_MOUSE (69-287): 5.09e-40: 156: 21.68		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		1326803 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		MFHA1_HUMAN (79-386): 6.54e-31: 134: 35.37
+	Hs
		280067 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		1021560 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		280050 KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		1301440 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		280084 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		1021531 KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68