Protein: SMC4
Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog)

Gene: SMC4
Organism: Homo sapiens
Interactions: 213
UniProt ID: Q9NTJ3

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000775 - chromosome, centromeric region
GO:0000794 - condensed nuclear chromosome
GO:0000796 - condensin complex
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

334110

SMC2
Structural maintenance of chromosomes protein 2

15

16

Small-scale

0.981

High

1136075

CND2
Condensin complex subunit 2

6

8

Small-scale

0.947

High

841263

CNDD3
Condensin-2 complex subunit D3

2

19

High-throughput

0.776

High

1233804

CNDH2
Condensin-2 complex subunit H2

4

3

Small-scale

0.699

High

373265

MYC
Myc proto-oncogene protein

4

14

High-throughput

0.694

High

1409670

CND3
Condensin complex subunit 3

4

10

Small-scale

0.686

High

1039418

RL6
Large ribosomal subunit protein eL6

3

1

High-throughput

0.640

High

397034

ESR1
Estrogen receptor

3

14

Small-scale

0.633

High

238623

RAD21
Double-strand-break repair protein rad21 homolog

1

20

High-throughput

0.618

High

1137278

CND1
Condensin complex subunit 1

1

19

Small-scale

0.618

High

1117508

SPTN1
Spectrin alpha chain, non-erythrocytic 1

2

11

High-throughput

0.601

High

1351596

MIPT3
TRAF3-interacting protein 1

2

6

High-throughput

0.590

High

129469

MEN1
Menin

2

4

High-throughput

0.584

High

260514

BRD4
Bromodomain-containing protein 4

2

12

High-throughput

0.584

High

537976

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.584

High

589810

RFA2
Replication protein A 32 kDa subunit

2

4

High-throughput

0.584

High

696628

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.584

High

769296

RFA3
Replication protein A 14 kDa subunit

2

4

High-throughput

0.584

High

831503

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

862490

YAP1
Transcriptional coactivator YAP1

2

9

Small-scale

0.584

High

1194406

LARP7
La-related protein 7

2

4

High-throughput

0.584

High

1447317

ANLN
Anillin

2

4

High-throughput

0.584

High

133135

FOXE1
Forkhead box protein E1

1

17

High-throughput

0.536

High

158506

RFXK
DNA-binding protein RFXANK

1

12

High-throughput

0.536

High

212037

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

7

High-throughput

0.536

High

288140

FOXH1
Forkhead box protein H1

1

18

High-throughput

0.536

High

297322

SERF1
Small EDRK-rich factor 1

1

1

High-throughput

0.536

High

564433

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

596785

DPEP1
Dipeptidase 1

1

1

High-throughput

0.536

High

841029

FRK
Tyrosine-protein kinase FRK

1

5

High-throughput

0.536

High

937658

FOXG1
Forkhead box protein G1

1

16

High-throughput

0.536

High

1091356

FOXL1
Forkhead box protein L1

1

15

High-throughput

0.536

High

1111300

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1289374

ST32C
Serine/threonine-protein kinase 32C

1

3

High-throughput

0.536

High

1347878

RIN3
Ras and Rab interactor 3

1

5

High-throughput

0.536

High

1351885

NEK7
Serine/threonine-protein kinase Nek7

1

10

High-throughput

0.536

High

1383870

EFMT3
EEF1A lysine methyltransferase 3

1

7

High-throughput

0.536

High

1387276

HDA11
Histone deacetylase 11

1

12

High-throughput

0.536

High

1404439

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

1406191

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

7

High-throughput

0.536

High

1407762

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

1420505

FOXQ1
Forkhead box protein Q1

1

18

High-throughput

0.536

High

1434651

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

1449554

HECD1
E3 ubiquitin-protein ligase HECTD1

2

9

Small-scale

0.533

High

1357429

DEP1B
DEP domain-containing protein 1B

2

2

High-throughput

0.521

High

584587

VAV
Proto-oncogene vav

1

7

High-throughput

0.515

High

683524

IKBA
NF-kappa-B inhibitor alpha

1

13

Small-scale

0.515

High

239220

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

334253

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

1420230

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1449553

INTU
Protein inturned

1

0

High-throughput

0.513

High

951870

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.501

High

964474

SUMO2
Small ubiquitin-related modifier 2

1

8

High-throughput

0.501

High

718474

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.489

High

1142190

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.489

High

1216408

FAXC
Failed axon connections homolog

1

1

High-throughput

0.489

High

1291694

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1336070

ARRD4
Arrestin domain-containing protein 4

1

5

High-throughput

0.489

High

1430975

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.489

High

1435936

IFT22
Intraflagellar transport protein 22 homolog

1

2

High-throughput

0.489

High

1449561

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.489

High

355037

CHK2
Serine/threonine-protein kinase Chk2

1

8

Small-scale

0.484

High

125631

LEG9
Galectin-9

1

5

High-throughput

0.479

High

157907

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.479

High

159876

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

223366

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

247444

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

6

High-throughput

0.479

High

286088

SF3B1
Splicing factor 3B subunit 1

1

4

High-throughput

0.479

High

294397

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

325127

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

334588

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

6

Small-scale

0.479

High

346389

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

350148

SNAI1
Zinc finger protein SNAI1

1

9

High-throughput

0.479

High

376912

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.479

High

406699

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.479

High

412677

NTRK1
High affinity nerve growth factor receptor

1

11

High-throughput

0.479

High

456866

ANXA2
Annexin A2

1

4

High-throughput

0.479

High

461971

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

607150

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

659609

CRCM
Colorectal mutant cancer protein

1

6

High-throughput

0.479

High

668040

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.479

High

731639

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

846493

MATR3
Matrin-3

1

3

High-throughput

0.479

High

861309

MAP1B
Microtubule-associated protein 1B

1

12

High-throughput

0.479

High

879511

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

883338

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

885713

CASP4
Caspase-4

1

4

High-throughput

0.479

High

897992

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.479

High

920304

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.479

High

959269

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

971154

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

980410

H4
Histone H4

1

5

High-throughput

0.479

High

984302

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

1026554

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1033792

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

1040926

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

1067757

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1100437

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.479

High

1102762

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.479

High

1107255

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1108197

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1110122

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

1114417

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1121346

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

1122568

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

1137541

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1138090

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1138680

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1141966

EEA1
Early endosome antigen 1

1

13

High-throughput

0.479

High

1155818

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

1193570

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

1220836

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1227540

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

1229705

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1241812

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1247014

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1250673

BCOR
BCL-6 corepressor

1

14

High-throughput

0.479

High

1258393

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

1270826

RUFY3
Protein RUFY3

1

9

High-throughput

0.479

High

1271878

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

1276848

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1288589

ZN598
E3 ubiquitin-protein ligase ZNF598

1

5

High-throughput

0.479

High

1310174

GCC2
GRIP and coiled-coil domain-containing protein 2

1

10

High-throughput

0.479

High

1329895

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

Small-scale

0.479

High

1338392

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1340820

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1352777

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1358115

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1364275

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.479

High

1364616

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1367382

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1372202

MED12
Mediator of RNA polymerase II transcription subunit 12

1

4

High-throughput

0.479

High

1380664

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1388647

SPDLY
Protein Spindly

1

10

High-throughput

0.479

High

1397472

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1404591

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

1404789

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.479

High

1407908

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1410148

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

1

High-throughput

0.479

High

1411725

RIOK1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

1413317

DIDO1
Death-inducer obliterator 1

1

14

High-throughput

0.479

High

1417068

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

1417492

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

1430596

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1431190

DUS15
Dual specificity protein phosphatase 15

1

3

High-throughput

0.479

High

1431620

AL8A1
2-aminomuconic semialdehyde dehydrogenase

1

1

High-throughput

0.479

High

1435346

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1436809

WDR76
WD repeat-containing protein 76

1

7

High-throughput

0.479

High

1438924

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

1446396

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

1448200

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1448278

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1449546

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1449548

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

5

High-throughput

0.479

High

1449549

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1449550

PD1L1
Programmed cell death 1 ligand 1

1

6

Small-scale

0.479

High

1449552

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1449555

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1449556

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

3

High-throughput

0.479

High

1449557

CC14A
Dual specificity protein phosphatase CDC14A

1

11

High-throughput

0.479

High

1449558

TRI33
E3 ubiquitin-protein ligase TRIM33

1

13

High-throughput

0.479

High

1449562

NINL
Ninein-like protein

1

12

High-throughput

0.479

High

1449564

NEMO
NF-kappa-B essential modulator

1

13

High-throughput

0.479

High

1178730

MGAL
Probable maltase-glucoamylase 2

1

2

High-throughput

0.470

High

719269

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

916360

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.458

High

1101051

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1416252

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.458

High

1448453

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.458

High

1449559

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.458

High

171590

S27A2
Long-chain fatty acid transport protein 2

1

5

High-throughput

0.445

High

430411

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

530439

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

675701

TYY1
Transcriptional repressor protein YY1

1

6

Small-scale

0.445

High

1023897

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.445

High

1108726

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

1209707

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1420734

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

1449544

S39A9
Zinc transporter ZIP9

1

3

High-throughput

0.445

High

1449551

DNM3B
DNA

1

1

Small-scale

0.445

High

175491

RIMB2
RIMS-binding protein 2

1

9

High-throughput

0.437

High

318889

RHBT1
Rho-related BTB domain-containing protein 1

1

6

High-throughput

0.437

High

576684

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

1

High-throughput

0.437

High

643093

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

699176

CALX
Calnexin

1

1

High-throughput

0.437

High

1120972

TRI29
Tripartite motif-containing protein 29

1

7

Small-scale

0.437

High

1249252

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1250202

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1255736

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1327224

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1348534

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.437

High

1393737

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1416689

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1434007

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

1449545

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

49023

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

553084

PIP
Prolactin-inducible protein

1

0

High-throughput

0.426

High

1326110

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

887257

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

1137

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

62599

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

166426

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.407

High

1240967

S27A4
Long-chain fatty acid transport protein 4

1

5

High-throughput

0.407

High

1243668

S27A1
Long-chain fatty acid transport protein 1

1

5

High-throughput

0.407

High

1314003

S35F3
Solute carrier family 35 member F3

1

1

High-throughput

0.407

High

1335743

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

1381032

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

1412073

S39A3
Zinc transporter ZIP3

1

3

High-throughput

0.407

High

1449547

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

720059

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.249

Low

1332903

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1449563

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low

1449560

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025