HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37005481
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~WW, WW~WW
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 1606
+	Hs
		125652 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		1294834 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		808226 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		808235 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		808278 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		808041 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		1334870 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SMUF2_HUMAN (1017-1606): 0: 646: 35.34
+	Hs
		1336083 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SMUF1_HUMAN (1034-1606): 0: 611: 33.82
+	Hs
		124986 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		125703 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		1294856 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Mm
		808342 NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98		NEDD4_MOUSE (754-1107): 6.29e-24: 111: 17.94
+	Hs
		125235 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		1327908 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		1299600 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Mm
		93257 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		E9PXB7_MOUSE (760-1062): 1.36e-13: 78.3: 17.82
+	Hs
		808736 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71