Protein: PDR5
Pleiotropic ABC efflux transporter of multiple drugs (Pleiotropic drug resistance protein 5) (Suppressor of toxicity of sporidesmin)

Gene: PDR5
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P33302

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0008559 - ABC-type xenobiotic transporter activity
GO:0009410 - response to xenobiotic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

704010

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

5

13

Small-scale

0.925

High

693454

SNQ2
Protein SNQ2

3

13

High-throughput

0.854

High

704062

PDR12
ATP-dependent permease PDR12

2

13

High-throughput

0.826

High

704078

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

13

High-throughput

0.723

High

704067

PDR15
ATP-dependent permease PDR15

1

13

High-throughput

0.618

High

393542

PMA1
Plasma membrane ATPase 1

2

3

High-throughput

0.614

High

690432

HXT1
Low-affinity glucose transporter HXT1

2

10

High-throughput

0.614

High

704075

TPO1
Polyamine transporter 1

2

20

High-throughput

0.613

High

704035

YNU8
Uncharacterized protein YNL208W

2

0

High-throughput

0.588

High

704018

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.584

High

698478

ZRT1
Zinc-regulated transporter 1

1

2

High-throughput

0.582

High

704091

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

2

High-throughput

0.582

High

510755

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.571

High

704028

SEO1
Probable transporter SEO1

1

10

High-throughput

0.560

High

704082

MCH5
Riboflavin transporter MCH5

1

8

High-throughput

0.560

High

704086

AIM41
Altered inheritance of mitochondria protein 41, mitochondrial

1

1

High-throughput

0.560

High

350802

RAS2
Ras-like protein 2

1

4

High-throughput

0.541

High

587237

HNM1
Choline transport protein

1

9

High-throughput

0.541

High

704014

SFK1
Protein SFK1

1

2

High-throughput

0.541

High

704020

HXT5
Probable glucose transporter HXT5

1

11

High-throughput

0.541

High

704030

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.541

High

704038

QDR2
Quinidine resistance protein 2

1

20

High-throughput

0.541

High

704056

TPO2
Polyamine transporter 2

1

20

High-throughput

0.541

High

704058

DIP5
Dicarboxylic amino acid permease

1

5

High-throughput

0.541

High

704074

FMP45
SUR7 family protein FMP45

1

3

High-throughput

0.541

High

704029

FLC2
Flavin carrier protein 2

2

2

High-throughput

0.537

High

704023

SMF2
Manganese transporter SMF2

1

0

High-throughput

0.536

High

679881

FUN26
Nucleoside transporter FUN26

1

0

High-throughput

0.518

High

704032

YND1
Golgi apyrase

1

0

High-throughput

0.518

High

704054

YG1I
Uncharacterized membrane protein YGR026W

1

0

High-throughput

0.518

High

704070

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.518

High

704088

CCW12
Covalently-linked cell wall protein 12

1

0

High-throughput

0.518

High

704092

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.518

High

667845

MCM5
Minichromosome maintenance protein 5

1

0

High-throughput

0.513

High

704071

ORM2
Protein ORM2

1

2

High-throughput

0.512

High

614594

KC11
Casein kinase I homolog 1

1

3

Small-scale

0.501

High

704034

TMN3
Transmembrane 9 superfamily member 3

1

1

High-throughput

0.494

High

704043

OST2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2

1

4

High-throughput

0.494

High

704053

SDS23
Protein SDS23

1

2

High-throughput

0.494

High

704059

COS1
Protein COS1

1

3

High-throughput

0.494

High

704090

POM33
Pore membrane protein of 33 kDa

1

1

High-throughput

0.494

High

541659

SEC63
Protein translocation protein SEC63

1

1

Small-scale

0.481

High

704080

NRT1
Nicotinamide riboside transporter 1

1

3

Small-scale

0.481

High

490763

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.479

High

543464

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

604862

GAS1
1,3-beta-glucanosyltransferase GAS1

1

3

High-throughput

0.479

High

680577

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

698036

FRE1
Ferric/cupric reductase transmembrane component 1

1

1

High-throughput

0.479

High

704012

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

704016

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

6

High-throughput

0.479

High

704017

ECM33
Cell wall protein ECM33

1

1

High-throughput

0.479

High

704024

FET3
Iron transport multicopper oxidase FET3

1

1

High-throughput

0.479

High

704025

ATU2
Copper-transporting ATPase

1

5

High-throughput

0.479

High

704044

TOH1
Probable circularly permuted 1,3-beta-glucanase YJL171C

1

1

High-throughput

0.479

High

704049

EXG2
Glucan 1,3-beta-glucosidase 2

1

3

High-throughput

0.479

High

704052

MNP1
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.479

High

704055

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

704057

MKC7
Aspartic proteinase MKC7

1

1

High-throughput

0.479

High

704063

ESP1
Separin

1

2

High-throughput

0.479

High

704065

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

3

High-throughput

0.479

High

704068

RM34
Large ribosomal subunit protein bL34m

1

1

High-throughput

0.479

High

704073

YL413
Cell membrane protein YLR413W

1

1

High-throughput

0.479

High

704076

LAM6
Membrane-anchored lipid-binding protein LAM6

1

1

High-throughput

0.479

High

704079

ENB1
Siderophore iron transporter ENB1

1

20

High-throughput

0.479

High

704013

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

1

High-throughput

0.470

High

704033

YES7
Putative uncharacterized protein YER097W

1

1

High-throughput

0.462

High

704039

HKR1
Signaling mucin HKR1

1

0

Small-scale

0.460

High

704040

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

Small-scale

0.460

High

704045

PRY3
Cell wall protein PRY3

1

0

Small-scale

0.460

High

704093

RAX2
Bud site selection protein RAX2

1

0

Small-scale

0.460

High

598597

UTR1
NAD(+) kinase

1

0

High-throughput

0.458

High

704026

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

704064

RSN1
Uncharacterized protein RSN1

1

0

High-throughput

0.458

High

704085

VPS68
Vacuolar protein sorting-associated protein 68

1

0

High-throughput

0.458

High

704077

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

Small-scale

0.457

High

704047

MUP1
High-affinity methionine permease

1

9

High-throughput

0.457

High

493560

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

704051

ERG25
C-4 methylsterol oxidase ERG25

1

2

High-throughput

0.445

High

704048

SC6B1
Protein transport protein SBH1

1

2

Small-scale

0.439

High

660309

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

661772

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

689232

SP110
Spindle pole body component 110

1

2

High-throughput

0.437

High

704027

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

704031

SS120
Protein SSP120

1

1

High-throughput

0.437

High

704037

TM108
Protein TMA108

1

1

High-throughput

0.437

High

704041

EMP47
Protein EMP47

1

2

High-throughput

0.437

High

704060

PGA2
Processing of GAS1 and ALP protein 2

1

1

High-throughput

0.437

High

704061

H3
Histone H3

1

1

High-throughput

0.437

High

704066

SXM1
Importin beta SMX1

1

2

High-throughput

0.437

High

704083

FLC1
Flavin carrier protein 1

1

2

High-throughput

0.437

High

704094

DFM1
DER1-like family member protein 1

1

2

Small-scale

0.437

High

704095

ENV10
SRP-independent targeting protein 2

1

4

High-throughput

0.437

High

704015

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

659141

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.407

High

704021

LAG1
Ceramide synthase LAG1

1

1

High-throughput

0.407

High

410347

SC160
Protein SCP160

2

0

Small-scale

0.306

High

704011

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.282

High

704036

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.282

High

704089

EMA19
Efficient mitochondria targeting-associated protein 19

1

0

High-throughput

0.282

High

704069

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.269

Low

704022

YAP3
AP-1-like transcription factor YAP3

1

0

Small-scale

0.251

Low

704042

OTU1
Ubiquitin thioesterase OTU1

1

0

Small-scale

0.251

Low

704046

ECM27
Protein ECM27

1

0

Small-scale

0.251

Low

704050

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

704087

TMS1
Membrane protein TMS1

1

0

Small-scale

0.251

Low

541539

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.249

Low

613052

SPA2
Protein SPA2

1

0

Small-scale

0.249

Low

644988

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

704019

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

704072

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

704081

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

704084

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

94

YA19A
Putative uncharacterized protein YAL019W-A

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024