Protein: PDR5
Pleiotropic ABC efflux transporter of multiple drugs (Pleiotropic drug resistance protein 5) (Suppressor of toxicity of sporidesmin)

Gene: PDR5
Organism: Saccharomyces cerevisiae S288C
Interactions: 117
UniProt ID: P33302

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0008559 - ABC-type xenobiotic transporter activity
GO:0009410 - response to xenobiotic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

751059

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

5

13

Small-scale

0.926

High

740321

SNQ2
Protein SNQ2

3

13

High-throughput

0.857

High

751113

PDR12
ATP-dependent permease PDR12

2

13

High-throughput

0.830

High

751129

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

13

High-throughput

0.733

High

656409

KC11
Casein kinase I homolog 1

1

3

Small-scale

0.647

High

751118

PDR15
ATP-dependent permease PDR15

1

13

High-throughput

0.618

High

420905

PMA1
Plasma membrane ATPase 1

2

3

High-throughput

0.614

High

737211

HXT1
Low-affinity glucose transporter HXT1

2

11

High-throughput

0.614

High

751126

TPO1
Polyamine transporter 1

2

20

High-throughput

0.613

High

751085

YNU8
Uncharacterized protein YNL208W

2

0

High-throughput

0.588

High

751068

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.584

High

745405

ZRT1
Zinc-regulated transporter 1

1

5

High-throughput

0.582

High

544311

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.571

High

751078

SEO1
Probable transporter SEO1

1

10

High-throughput

0.568

High

751133

MCH5
Riboflavin transporter MCH5

1

11

High-throughput

0.568

High

751137

AIM41
Altered inheritance of mitochondria protein 41, mitochondrial

1

1

High-throughput

0.568

High

751073

SMF2
Manganese transporter SMF2

1

0

High-throughput

0.543

High

376221

RAS2
Ras-like protein 2

1

6

High-throughput

0.541

High

625886

HNM1
Choline transporter

1

12

High-throughput

0.541

High

751063

SFK1
Protein SFK1

1

2

High-throughput

0.541

High

751070

HXT5
Probable glucose transporter HXT5

1

12

High-throughput

0.541

High

751080

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.541

High

751088

QDR2
Quinidine resistance protein 2

1

20

High-throughput

0.541

High

751107

TPO2
Polyamine transporter 2

1

20

High-throughput

0.541

High

751109

DIP5
Dicarboxylic amino acid permease

1

7

High-throughput

0.541

High

751125

FMP45
SUR7 family protein FMP45

1

3

High-throughput

0.541

High

751079

FLC2
Flavin carrier protein 2

2

2

High-throughput

0.537

High

751142

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

2

High-throughput

0.532

High

751122

ORM2
Protein ORM2

1

2

High-throughput

0.518

High

726060

FUN26
Nucleoside transporter FUN26

1

0

High-throughput

0.518

High

751082

YND1
Golgi apyrase

1

0

High-throughput

0.518

High

751105

YG1I
Uncharacterized membrane protein YGR026W

1

0

High-throughput

0.518

High

751121

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.518

High

751139

CCW12
Covalently-linked cell wall protein 12

1

0

High-throughput

0.518

High

751143

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.518

High

713255

MCM5
Minichromosome maintenance protein 5

1

0

High-throughput

0.513

High

751084

TMN3
Transmembrane 9 superfamily member 3

1

1

High-throughput

0.494

High

751094

OST2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2

1

4

High-throughput

0.494

High

751104

SDS23
Protein SDS23

1

2

High-throughput

0.494

High

751110

COS1
Protein COS1

1

3

High-throughput

0.494

High

751141

POM33
Pore membrane protein of 33 kDa

1

1

High-throughput

0.494

High

577079

SEC63
Protein translocation protein SEC63

1

2

Small-scale

0.481

High

751131

NRT1
Nicotinamide riboside transporter 1

1

3

Small-scale

0.481

High

523484

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.479

High

579116

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

645236

GAS1
1,3-beta-glucanosyltransferase GAS1

1

3

High-throughput

0.479

High

726894

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

744957

FRE1
Ferric/cupric reductase transmembrane component 1

1

1

High-throughput

0.479

High

751061

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

751065

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

11

High-throughput

0.479

High

751067

ECM33
Cell wall protein ECM33

1

1

High-throughput

0.479

High

751074

FET3
Iron transport multicopper oxidase FET3

1

1

High-throughput

0.479

High

751075

ATU2
Copper-transporting ATPase

1

6

High-throughput

0.479

High

751095

TOH1
Probable circularly permuted 1,3-beta-glucanase YJL171C

1

1

High-throughput

0.479

High

751100

EXG2
Glucan 1,3-beta-glucosidase 2

1

3

High-throughput

0.479

High

751103

MNP1
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.479

High

751106

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

751108

MKC7
Aspartic proteinase MKC7

1

1

High-throughput

0.479

High

751114

ESP1
Separin

1

2

High-throughput

0.479

High

751116

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

3

High-throughput

0.479

High

751119

RM34
Large ribosomal subunit protein bL34m

1

1

High-throughput

0.479

High

751124

YL413
Cell membrane protein YLR413W

1

1

High-throughput

0.479

High

751127

LAM6
Membrane-anchored lipid-binding protein LAM6

1

1

High-throughput

0.479

High

751130

ENB1
Siderophore iron transporter ENB1

1

20

High-throughput

0.479

High

751144

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

751062

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

1

High-throughput

0.470

High

751083

YES7
Putative uncharacterized protein YER097W

1

1

High-throughput

0.462

High

751090

HKR1
Signaling mucin HKR1

1

0

Small-scale

0.460

High

751091

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

Small-scale

0.460

High

751096

PRY3
Cell wall protein PRY3

1

0

Small-scale

0.460

High

751145

RAX2
Bud site selection protein RAX2

1

0

Small-scale

0.460

High

638032

UTR1
NAD(+) kinase

1

0

High-throughput

0.458

High

751076

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

751115

RSN1
Uncharacterized protein RSN1

1

0

High-throughput

0.458

High

751136

VPS68
Vacuolar protein sorting-associated protein 68

1

0

High-throughput

0.458

High

751128

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

1

Small-scale

0.457

High

751098

MUP1
High-affinity methionine permease

1

14

High-throughput

0.457

High

526284

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

751102

ERG25
C-4 methylsterol oxidase ERG25

1

2

High-throughput

0.445

High

751099

SC6B1
Protein transport protein SBH1

1

2

Small-scale

0.439

High

705153

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

706642

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

735983

SP110
Spindle pole body component 110

1

2

High-throughput

0.437

High

751077

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

751081

SS120
Protein SSP120

1

1

High-throughput

0.437

High

751087

TM108
Protein TMA108

1

1

High-throughput

0.437

High

751089

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

751092

EMP47
Protein EMP47

1

2

High-throughput

0.437

High

751111

PGA2
Processing of GAS1 and ALP protein 2

1

1

High-throughput

0.437

High

751112

H3
Histone H3

1

1

High-throughput

0.437

High

751117

SXM1
Importin beta SMX1

1

2

High-throughput

0.437

High

751134

FLC1
Flavin carrier protein 1

1

2

High-throughput

0.437

High

751146

DFM1
DER1-like family member protein 1

1

3

Small-scale

0.437

High

751147

ENV10
SRP-independent targeting protein 2

1

4

High-throughput

0.437

High

751064

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

703798

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.407

High

751071

LAG1
Ceramide synthase LAG1

1

1

High-throughput

0.407

High

438658

SC160
Protein SCP160

2

0

Small-scale

0.306

High

751060

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.282

High

751086

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.282

High

751140

EMA19
Efficient mitochondria targeting-associated protein 19

1

0

High-throughput

0.282

High

751120

CSM3
Chromosome segregation in meiosis protein 3

1

0

High-throughput

0.269

Low

751072

YAP3
AP-1-like transcription factor YAP3

1

0

Small-scale

0.251

Low

751093

OTU1
Ubiquitin thioesterase OTU1

1

0

Small-scale

0.251

Low

751097

ECM27
Protein ECM27

1

0

Small-scale

0.251

Low

751101

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

751138

TMS1
Membrane protein TMS1

1

0

Small-scale

0.251

Low

576958

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.249

Low

654714

SPA2
Protein SPA2

1

0

Small-scale

0.249

Low

688989

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

751066

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

751069

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

751123

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

751132

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

751135

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

94

YA19A
Putative uncharacterized protein YAL019W-A

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025