HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	34079125, 38280479, 24255178
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 1190
+	Hs
		1327931 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		125403 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		808542 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		990928 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Mm
		1143429 NED4L_MOUSE (4-504): 5.54e-115: 364: 19.73		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		93273 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		125577 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		808565 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Hs
		1232500 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		808764 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		808185 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		1271021 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		DLG3_HUMAN (2-318): 5.99e-23: 107: 16.61
+	Dm
		1367280 SUDX_DROME (16-504): 4.46e-109: 347: 15.74		Q9VHK4_DROME (24-347): 4.82e-23: 108: 21.17
+	Mm
		93267 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10
+	Mm
		808344 NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98		DLG3_MOUSE (372-595): 5.97e-13: 75.5: 18.10
+	Mm
		809081 YAP1_MOUSE (35-504): 1.41e-115: 351: 91.70		PALS1_MOUSE (3-296): 9.91e-12: 71.3: 10.32
+	Dm
		1367276 NEDD4_DROME (127-504): 5.99e-94: 308: 18.47		Q9VHK4_DROME (24-347): 4.82e-23: 108: 21.17
+	Hs
		1021560 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Hs
		1232499 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Mm
		1322235 WWTR1_MOUSE (39-504): 9.89e-56: 193: 38.90		PALS1_MOUSE (3-296): 9.91e-12: 71.3: 10.32