HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: SHAN1 (Q9Y566)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
Gene: SHANK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0065003 - protein-containing complex assembly
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 2161
+	Hs
		125583 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ANR44_HUMAN (6-512): 1.73e-91: 323: 14.94
+	Hs
		1326807 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SHAN1_HUMAN (1-2161): 4.7e-149: 516: 100.00
+	Hs
		125054 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		PSD10_HUMAN (222-419): 8.16e-65: 222: 28.36
+	Hs
		1336115 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		ANR50_HUMAN (8-319): 3.8e-64: 244: 15.92
+	Hs
		276153 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PSD10_HUMAN (222-419): 8.16e-65: 222: 28.36
+	Hs
		808564 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Hs
		808109 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Mm
		1116029 NED4L_MOUSE (4-504): 5.54e-115: 364: 19.73		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Mm
		93271 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Mm
		808351 NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Hs
		1316279 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Hs
		808975 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		RAI14_HUMAN (182-406): 1.78e-14: 81.6: 29.20
+	Hs
		862101 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		DAPK1_HUMAN (221-642): 6.21e-61: 233: 13.90
+	Hs
		1021456 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Hs
		1326761 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		RAI14_HUMAN (182-406): 1.78e-14: 81.6: 29.20
+	Mm
		1116041 HECW1_MOUSE (20-222): 8.56e-24: 107: 15.86		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Hs
		1176346 HECW1_HUMAN (2-222): 1.33e-24: 110: 14.96		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Hs
		1349044 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		ANKR6_HUMAN (165-266): 5.59e-12: 73.4: 19.61