HitPredict

Interactor 1: RRP41 (P46948)
Exosome complex component SKI6 (Extracellular mutant protein 20) (Ribosomal RNA-processing protein 41) (Superkiller protein 6)
Gene: SKI6

Interactor 2: RRP45 (Q05636)
Exosome complex component RRP45 (Ribosomal RNA-processing protein 45)
Gene: RRP45

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 10655498, 15951817, 11283351, 11805826, 17173052, 12837249, 16554755, 16429126, 17391830, 37968396, 14759368, 18314965, 19879841, 16729021
Identification Methods two hybrid, pull down, molecular sieving, two hybrid pooling approach, ion exchange chromatography, tandem affinity purification, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNase_PH~RNase_PH, RNase_PH~RNase_PH_C, RNase_PH_C~RNase_PH_C
Common GO terms GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
and 9 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 246
Sc

1 305
+ Sp
+ At
+ At
+ Hs
+ Hs
+ Ss
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ Mt
+ Sp
+ At
+ Dm
+ Dm
+ At
+ Hs
+ Sp
+ Sc

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Last updated: 15 Jul 2024