HitPredict

Interactor 1: AP3S (P47064)
AP-3 complex subunit sigma (AP-3 complex sigma3A subunit) (Adaptor-related protein complex 3 subunit sigma) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-adaptin 3A) (Sigma3-adaptin)
Gene: APS3

Interactor 2: AP3D (Q08951)
AP-3 complex subunit delta (Adaptor-related protein complex 3 subunit delta) (Delta-adaptin 3) (Delta-adaptin)
Gene: APL5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.940

Property	Details
Experiments	11283351, 11805826, 16554755, 37968396, 34688652, 16429126
Identification Methods	two hybrid pooling approach, tandem affinity purification, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005794 - Golgi apparatus GO:0006623 - protein targeting to vacuole GO:0006886 - intracellular protein transport GO:0006896 - Golgi to vacuole transport GO:0030123 - AP-3 adaptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 194 Sc			1 932
+	Hs
		212614 AP1S1_HUMAN (1-176): 4.82e-66: 201: 27.27		AP1G1_HUMAN (26-846): 9.09e-176: 532: 15.78
+	Hs
		212611 AP1S2_HUMAN (2-175): 2.9e-65: 199: 28.16		AP1G1_HUMAN (26-846): 9.09e-176: 532: 15.78
+	Hs
		212659 AP1S3_HUMAN (1-161): 2.07e-59: 184: 27.95		AP1G1_HUMAN (26-846): 9.09e-176: 532: 15.78
+	Hs
		212608 AP2S1_HUMAN (1-160): 1.58e-57: 179: 29.38		AP1G1_HUMAN (26-846): 9.09e-176: 532: 15.78
+	Hs
		150247 AP3S1_HUMAN (1-164): 6.8e-68: 207: 44.51		AP3D1_HUMAN (21-919): 1.98e-151: 479: 26.50
+	Hs
		150196 AP3S2_HUMAN (1-163): 5.73e-66: 202: 42.95		AP3D1_HUMAN (21-919): 1.98e-151: 479: 26.50
+	Hs
		302125 AP2S1_HUMAN (1-160): 1.58e-57: 179: 29.38		AP2A2_HUMAN (25-846): 6.14e-155: 482: 16.40
+	Hs
		276362 AP1S1_HUMAN (1-176): 4.82e-66: 201: 27.27		AP1G2_HUMAN (27-835): 3.38e-148: 459: 14.62
+	Hs
		903681 AP1S1_HUMAN (1-176): 4.82e-66: 201: 27.27		AP2B1_HUMAN (39-776): 2.38e-146: 459: 13.77
+	Hs
		903682 AP1S1_HUMAN (1-176): 4.82e-66: 201: 27.27		AP1B1_HUMAN (39-701): 9.88e-146: 458: 14.58
+	Hs
		276360 AP1S2_HUMAN (2-175): 2.9e-65: 199: 28.16		AP1G2_HUMAN (27-835): 3.38e-148: 459: 14.62
+	Hs
		880408 AP1S2_HUMAN (2-175): 2.9e-65: 199: 28.16		AP2B1_HUMAN (39-776): 2.38e-146: 459: 13.77
+	Hs
		880409 AP1S2_HUMAN (2-175): 2.9e-65: 199: 28.16		AP1B1_HUMAN (39-701): 9.88e-146: 458: 14.58
+	Dm
		1362881 Q9VCF4_DROME (1-176): 1.43e-60: 187: 26.71		Q9W388_DROME (23-772): 9.92e-146: 458: 16.28
+	Hs
		276385 AP1S3_HUMAN (1-161): 2.07e-59: 184: 27.95		AP1G2_HUMAN (27-835): 3.38e-148: 459: 14.62
+	Hs
		925978 AP1S3_HUMAN (1-161): 2.07e-59: 184: 27.95		AP2B1_HUMAN (39-776): 2.38e-146: 459: 13.77
+	Hs
		1014066 AP1S3_HUMAN (1-161): 2.07e-59: 184: 27.95		AP1B1_HUMAN (39-701): 9.88e-146: 458: 14.58
+	Dm
		1182762 Q9VCF4_DROME (1-176): 1.43e-60: 187: 26.71		Q7KVR8_DROME (26-632): 8.13e-144: 454: 19.15
+	Dm
		1096906 Q9VDC3_DROME (1-160): 2.84e-58: 181: 29.38		Q24253_DROME (39-699): 1.83e-144: 454: 13.99
+	Dm
		954832 Q9VDC3_DROME (1-160): 2.84e-58: 181: 29.38		AP2A_DROME (25-667): 4.96e-140: 443: 19.36