HitPredict

Interactor 1: ARP3 (P47117)
Actin-related protein 3 (Actin-like protein ARP3) (Actin-like protein 3)
Gene: ARP3

Interactor 2: LAS17 (Q12446)
Proline-rich protein LAS17
Gene: LAS17

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	10322115, 27325766, 11533442, 29386393, 37968396, 38367669, 21035341
Identification Methods	coimmunoprecipitation, pull down, x-ray crystallography, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Actin~WH2
Common GO terms	GO:0030479 - actin cortical patch GO:0045010 - actin nucleation
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 449 Sc			1 633
+	Sp
		193727 ARP3_SCHPO (1-446): 0: 606: 68.01		WSP1_SCHPO (4-416): 3.99e-22: 102: 22.03
+	Sc
		887724 ACT_YEAST (1-444): 0: 511: 32.44		LAS17_YEAST (1-633): 8.22e-51: 188: 100.00
+	Hs
		126926 ACTB_HUMAN (1-444): 0: 520: 32.44		WASL_HUMAN (3-154): 1.13e-42: 163: 28.29
+	Hs
		126931 ACTG_HUMAN (3-444): 0: 520: 32.36		WASL_HUMAN (3-154): 1.13e-42: 163: 28.29
+	Hs
		126932 ACTC_HUMAN (2-444): 0: 515: 32.29		WASL_HUMAN (3-154): 1.13e-42: 163: 28.29
+	Hs
		126928 ARP3_HUMAN (7-449): 6.34e-172: 490: 58.35		WASL_HUMAN (3-154): 1.13e-42: 163: 28.29
+	Bt
		896714 ARP3_BOVIN (7-449): 6.34e-172: 490: 58.35		WASL_BOVIN (3-154): 5.52e-38: 149: 28.29
+	Hs
		203220 ACTC_HUMAN (2-444): 0: 515: 32.29		SYNJ1_HUMAN (89-538): 6.62e-22: 103: 12.06
+	Hs
		554290 ACTA_HUMAN (2-444): 0: 512: 32.51		MUC1_HUMAN (148-625): 1.36e-21: 102: 14.37
+	Hs
		790654 ARP3_HUMAN (7-449): 6.34e-172: 490: 58.35		WASP_HUMAN (3-448): 2.5e-27: 117: 16.52
+	Hs
		896772 ARP3_HUMAN (7-449): 6.34e-172: 490: 58.35		MICA3_HUMAN (141-632): 1.68e-24: 111: 14.66
+	Hs
		891853 ACTB_HUMAN (1-444): 0: 520: 32.44		SRCAP_HUMAN (101-624): 2.28e-09: 62.9: 11.78
+	Hs
		929905 ACTG_HUMAN (3-444): 0: 520: 32.36		SRCAP_HUMAN (101-624): 2.28e-09: 62.9: 11.78
+	Hs
		932156 ACTC_HUMAN (2-444): 0: 515: 32.29		MDC1_HUMAN (132-620): 1.5e-09: 63.6: 11.20
+	Hs
		932219 ACTC_HUMAN (2-444): 0: 515: 32.29		SRCAP_HUMAN (101-624): 2.28e-09: 62.9: 11.78
+	Sp
		193726 ACT_SCHPO (8-440): 3.33e-80: 254: 34.93		WSP1_SCHPO (4-416): 3.99e-22: 102: 22.03