HitPredict

Interactor 1: B7Z0T5 (B7Z0T5)
Metastasis associated 1-like, isoform C
Gene: MTA1-like

Interactor 2: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27117189, 22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005654 - nucleoplasm GO:0016581 - NuRD complex and 1 others more... GO:0030261 - chromosome condensation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 853 Dm			1 521
+	Dm
		1276548 Q9VNF6_DROME (12-853): 0: 694: 94.99		HDAC1_DROME (1-521): 0: 674: 100.00
+	Hs
		1031919 MTA1_HUMAN (12-837): 1.71e-175: 525: 36.69		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Mm
		936419 MTA1_MOUSE (12-837): 6.55e-171: 513: 36.69		HDAC2_MOUSE (2-488): 0: 655: 76.18
+	Hs
		1031849 MTA1_HUMAN (12-837): 1.71e-175: 525: 36.69		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Mm
		140302 MTA1_MOUSE (12-837): 6.55e-171: 513: 36.69		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		1270415 MTA3_HUMAN (12-613): 1.95e-162: 487: 40.23		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		296092 MTA2_HUMAN (12-769): 5.35e-161: 486: 35.61		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Mm
		936428 MTA2_MOUSE (12-769): 1.13e-162: 490: 35.61		HDAC2_MOUSE (2-488): 0: 655: 76.18
+	Mm
		140317 MTA2_MOUSE (12-769): 1.13e-162: 490: 35.61		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		91458 E7EQY4_HUMAN (12-557): 5.27e-164: 488: 43.42		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1038676 MTA3_HUMAN (12-613): 1.95e-162: 487: 40.23		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		296017 MTA2_HUMAN (12-769): 5.35e-161: 486: 35.61		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1270490 RERE_HUMAN (15-776): 5.58e-103: 351: 19.87		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1038770 RERE_HUMAN (15-776): 5.58e-103: 351: 19.87		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1270488 RCOR3_HUMAN (205-735): 2.73e-72: 247: 15.64		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1270515 RCOR1_HUMAN (203-629): 1.72e-64: 226: 13.07		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1038768 RCOR3_HUMAN (205-735): 2.73e-72: 247: 15.64		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1038801 RCOR1_HUMAN (203-629): 1.72e-64: 226: 13.07		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		177395 RCOR3_HUMAN (205-735): 2.73e-72: 247: 15.64		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Hs
		177402 RCOR1_HUMAN (203-629): 1.72e-64: 226: 13.07		HDAC3_HUMAN (6-427): 0: 572: 56.37