HitPredict - High confidence protein-protein interactions

Interactor 1: PI42A (P48426)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)
Gene: PIP4K2A

Interactor 2: PI42C (Q8TBX8)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)
Gene: PIP4K2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	33961781, 35271311, 28514442, 24981860, 35235311
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PIP5K~PIP5K
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005776 - autophagosome GO:0005829 - cytosol GO:0005886 - plasma membrane and 8 others more... GO:0010506 - regulation of autophagy GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016309 - 1-phosphatidylinositol-5-phosphate 4-kinase activity GO:0016310 - phosphorylation GO:0046627 - negative regulation of insulin receptor signaling pathway GO:0046854 - phosphatidylinositol phosphate biosynthetic process GO:1902635 - 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process GO:2000786 - positive regulation of autophagosome assembly
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	406
Hs

1	421

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Last updated: 15 Jul 2024