Protein: INO80
Chromatin-remodeling ATPase INO80 (EC 3.6.4.-) (Inositol-requiring protein 80)

Gene: INO80
Organism: Saccharomyces cerevisiae S288C
Interactions: 137
UniProt ID: P53115

Gene Ontology (top 5):
GO:0000722 - telomere maintenance via recombination
GO:0000775 - chromosome, centromeric region
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

917340

ARP8
Actin-like protein ARP8

22

20

Small-scale

0.988

High

917341

RUVB2
RuvB-like protein 2

21

20

Small-scale

0.988

High

917308

ARP4
Actin-related protein 4

21

20

Small-scale

0.986

High

917318

RUVB1
RuvB-like protein 1

19

20

Small-scale

0.986

High

917306

ACT
Actin

19

20

Small-scale

0.986

High

917303

ARP5
Actin-related protein 5

16

20

Small-scale

0.983

High

820292

IES2
Ino eighty subunit 2

13

2

Small-scale

0.975

High

381176

H2B1
Histone H2B.1

5

20

Small-scale

0.906

High

419465

H2A1
Histone H2A.1

4

20

Small-scale

0.878

High

382229

H4
Histone H4

4

16

Small-scale

0.873

High

917307

H3
Histone H3

4

20

Small-scale

0.873

High

917315

NHP10
Non-histone protein 10

19

20

Small-scale

0.764

High

763351

TAF14
Transcription initiation factor TFIID subunit 14

19

8

Small-scale

0.764

High

917339

IES3
Ino eighty subunit 3

17

2

Small-scale

0.761

High

849881

IES1
Ino eighty subunit 1

16

1

Small-scale

0.761

High

743839

IES6
Chromatin-remodeling complex subunit IES6

14

3

Small-scale

0.757

High

817702

IES5
Ino eighty subunit 5

14

1

Small-scale

0.757

High

917331

IES4
Ino eighty subunit 4

14

1

Small-scale

0.757

High

917299

INO80
Chromatin-remodeling ATPase INO80

2

18

Small-scale

0.754

High

419813

H2A2
Histone H2A.2

2

20

Small-scale

0.737

High

381571

H2B2
Histone H2B.2

1

20

Small-scale

0.618

High

402061

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

9

Small-scale

0.618

High

594478

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.618

High

734448

BTAF1
TATA-binding protein-associated factor MOT1

1

16

Small-scale

0.618

High

779292

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.618

High

826387

MPH1
ATP-dependent DNA helicase MPH1

1

20

High-throughput

0.618

High

809275

MET30
F-box protein MET30

1

15

High-throughput

0.590

High

647805

RFA1
Replication factor A protein 1

2

12

Small-scale

0.584

High

689780

INO2
Protein INO2

2

0

Small-scale

0.577

High

792149

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.575

High

679892

CDC48
Cell division control protein 48

1

5

Small-scale

0.561

High

739895

RPD3
Histone deacetylase RPD3

1

20

Small-scale

0.561

High

793440

ATR
Serine/threonine-protein kinase MEC1

1

10

Small-scale

0.561

High

527217

HSP72
Heat shock protein SSA2

2

17

High-throughput

0.552

High

836142

FKH2
Fork head protein homolog 2

1

20

High-throughput

0.536

High

917314

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.536

High

917325

PDP3
NuA3 HAT complex component PDP3

1

10

Small-scale

0.536

High

466795

SWI5
Transcriptional factor SWI5

1

12

Small-scale

0.501

High

550065

RAP1
DNA-binding protein RAP1

1

1

Small-scale

0.501

High

575484

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.489

High

813562

MET10
Sulfite reductase [NADPH] flavoprotein component

1

2

High-throughput

0.489

High

836652

GLDS1
Protein GDS1

1

0

High-throughput

0.486

High

395258

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.480

High

473522

LEUR
Regulatory protein LEU3

1

0

Small-scale

0.480

High

575255

RAD4
DNA repair protein RAD4

1

2

Small-scale

0.479

High

707686

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

709880

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

735071

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

750871

PRS6B
26S proteasome regulatory subunit 6B homolog

1

3

Small-scale

0.479

High

750978

PRS7
26S proteasome regulatory subunit 7 homolog

1

8

Small-scale

0.479

High

763943

SPT10
Protein SPT10

1

3

High-throughput

0.479

High

776617

DEF1
RNA polymerase II degradation factor 1

1

5

Small-scale

0.479

High

795648

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

7

Small-scale

0.479

High

798605

PAF1
RNA polymerase II-associated protein 1

1

3

Small-scale

0.479

High

800260

LEO1
RNA polymerase-associated protein LEO1

1

5

Small-scale

0.479

High

815952

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

7

Small-scale

0.479

High

826670

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.479

High

850106

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

10

Small-scale

0.479

High

858447

TAF1
Transcription initiation factor TFIID subunit 1

1

4

High-throughput

0.479

High

864595

UBX6
UBX domain-containing protein 6

1

1

Small-scale

0.479

High

917300

H1
Histone H1

1

1

Small-scale

0.479

High

917305

ORC1
Origin recognition complex subunit 1

1

7

High-throughput

0.479

High

917309

CTR9
RNA polymerase-associated protein CTR9

1

12

Small-scale

0.479

High

917317

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

6

High-throughput

0.479

High

917319

RPN9
26S proteasome regulatory subunit RPN9

1

2

Small-scale

0.479

High

917320

SIZ1
E3 SUMO-protein ligase SIZ1

1

6

High-throughput

0.479

High

917324

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

917328

CDC73
Cell division control protein 73

1

2

Small-scale

0.479

High

917334

SCC1
Sister chromatid cohesion protein 1

1

5

High-throughput

0.479

High

917335

SIZ2
E3 SUMO-protein ligase SIZ2

1

5

High-throughput

0.479

High

150298

RPN13
26S proteasome regulatory subunit RPN13

1

0

Small-scale

0.458

High

314894

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

649229

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

661544

PSA2
Proteasome subunit alpha type-2

1

0

Small-scale

0.458

High

735943

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

738329

RPN12
26S proteasome regulatory subunit RPN12

1

0

Small-scale

0.458

High

792703

GLRX7
Monothiol glutaredoxin-7

1

0

High-throughput

0.458

High

874328

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

Small-scale

0.458

High

916874

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.458

High

917304

UBX4
UBX domain-containing protein 4

1

0

Small-scale

0.458

High

917312

ESP1
Separin

1

0

High-throughput

0.458

High

917321

LCD1
DNA damage checkpoint protein LCD1

1

0

Small-scale

0.458

High

917323

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

917337

MDY2
Ubiquitin-like protein MDY2

1

0

Small-scale

0.458

High

393054

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

416139

SYTC
Threonine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.445

High

448197

HAP2
Transcriptional activator HAP2

1

3

High-throughput

0.445

High

524603

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

545615

SSB1
Ribosome-associated molecular chaperone SSB1

1

16

High-throughput

0.445

High

547810

NHP6A
Non-histone chromosomal protein 6A

1

20

High-throughput

0.445

High

554029

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.445

High

579764

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.445

High

592381

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.445

High

597216

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.445

High

645625

AFT1
Iron-regulated transcriptional activator AFT1

1

1

High-throughput

0.445

High

676180

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

684786

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.445

High

727192

HS104
Heat shock protein 104

1

5

High-throughput

0.445

High

736683

ASF1
Histone chaperone ASF1

1

10

High-throughput

0.445

High

737642

HIR1
Protein HIR1

1

20

High-throughput

0.445

High

739415

ZUO1
Zuotin

1

6

High-throughput

0.445

High

742008

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752524

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

781771

SET3
SET domain-containing protein 3

1

17

High-throughput

0.445

High

804307

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

810732

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.445

High

820426

RT106
Histone chaperone RTT106

1

2

High-throughput

0.445

High

823004

ATAD2
ATPase histone chaperone YTA7

1

9

High-throughput

0.445

High

917310

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.445

High

917322

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

917330

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

917342

CAF1A
Chromatin assembly factor 1 subunit A

1

12

High-throughput

0.445

High

744002

RAD23
UV excision repair protein RAD23

1

4

Small-scale

0.437

High

798587

UBX7
UBX domain-containing protein 7

1

2

Small-scale

0.437

High

818506

SCC4
MAU2 chromatid cohesion factor homolog

1

3

Small-scale

0.437

High

917313

RT10
Small ribosomal subunit protein uS10m

1

3

High-throughput

0.437

High

917332

RPN8
26S proteasome regulatory subunit RPN8

1

6

Small-scale

0.437

High

917336

RPN5
26S proteasome regulatory subunit RPN5

1

2

Small-scale

0.437

High

453698

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

531362

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.426

High

358285

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.407

High

394746

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

858031

RSSA2
Small ribosomal subunit protein uS2B

1

3

High-throughput

0.407

High

917311

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.407

High

917327

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

7

High-throughput

0.407

High

917338

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

917343

ATG11
Autophagy-related protein 11

1

0

Small-scale

0.292

High

843225

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.249

Low

865319

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

917301

ATG2
Autophagy-related protein 2

1

0

Small-scale

0.249

Low

917302

PGA14
Hydrophilin YNL190W

1

0

High-throughput

0.249

Low

917316

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

917326

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.249

Low

917329

ATG20
Autophagy-related protein 20

1

0

Small-scale

0.249

Low

917333

ATG9
Autophagy-related protein 9

1

0

Small-scale

0.249

Low

836799

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025