HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: PELP1 (Q8IZL8)
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
Gene: PELP1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23667531
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1130
+	Hs
		1224538 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		PELP1_HUMAN (1-1130): 0: 788: 100.00
+	Hs
		818550 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		CHD7_HUMAN (487-1110): 6.96e-32: 137: 13.51
+	Hs
		817978 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		818266 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28
+	Hs
		818382 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MINT_HUMAN (731-1119): 1.09e-10: 68.5: 12.18
+	Mm
		57186 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		CHD7_MOUSE (495-1025): 1.2e-09: 65.1: 8.84
+	Hs
		727814 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		CHD7_HUMAN (487-1110): 6.96e-32: 137: 13.51
+	Mm
		818744 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		CHAP1_MOUSE (750-1123): 3.35e-09: 63.1: 12.37
+	Hs
		818841 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		CHD7_HUMAN (487-1110): 6.96e-32: 137: 13.51
+	Hs
		1332326 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		CHD7_HUMAN (487-1110): 6.96e-32: 137: 13.51
+	Hs
		881831 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		CHD7_HUMAN (487-1110): 6.96e-32: 137: 13.51
+	Hs
		818828 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Rn
		94293 SOX9_RAT (28-260): 3.95e-39: 145: 27.98		F1M9G7_RAT (631-1010): 7.91e-27: 121: 17.73
+	Hs
		1270803 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		CBP_HUMAN (631-1010): 2.14e-28: 126: 16.87
+	Hs
		818793 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		818819 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28
+	Hs
		1056996 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		MDC1_HUMAN (411-1014): 5.18e-12: 72.8: 11.24
+	Hs
		999121 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		881798 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		EP300_HUMAN (697-1081): 1.18e-11: 71.5: 11.17
+	Hs
		1243843 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		KMT2C_HUMAN (704-1130): 8.21e-11: 68.9: 9.28