HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: BRD8 (Q9H0E9)
Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)
Gene: BRD8

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23667531
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1235
+	Hs
		817983 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		BPTF_HUMAN (130-1222): 5.45e-42: 171: 9.55
+	Hs
		818613 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		TRI33_HUMAN (820-1232): 7.65e-33: 140: 11.56
+	Hs
		170296 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		818490 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		817978 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		818204 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		817810 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Hs
		170279 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		1332331 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		TRI33_HUMAN (820-1232): 7.65e-33: 140: 11.56
+	Hs
		818839 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		170476 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		TIF1A_HUMAN (845-1228): 4.33e-31: 134: 14.07
+	Hs
		818793 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		1332323 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		BRD7_HUMAN (1005-1212): 3.07e-29: 127: 15.02
+	Hs
		999121 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		EP300_HUMAN (807-1211): 2.38e-27: 123: 13.66
+	Hs
		818817 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		1199196 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		PB1_HUMAN (987-1226): 1.89e-22: 107: 15.45
+	Hs
		818785 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMCA4_HUMAN (1057-1208): 7.26e-19: 95.5: 13.84
+	Rn
		94293 SOX9_RAT (28-260): 3.95e-39: 145: 27.98		F1M9G7_RAT (161-548): 9.82e-09: 62.2: 12.75
+	Hs
		818828 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22
+	Hs
		1270803 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		CBP_HUMAN (125-595): 9.03e-09: 62.2: 12.22