HitPredict

Interactor 1: PRC2A (P48634)
Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)
Gene: PRRC2A

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29395067, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2157 Hs			1 406
+	Hs
		820918 PRC2A_HUMAN (1-2157): 4.11e-162: 555: 100.00		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		1051875 PRC2B_HUMAN (1-2145): 2.51e-121: 430: 25.60		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		640367 PRC2A_HUMAN (1-2157): 4.11e-162: 555: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		892824 PRC2B_HUMAN (1-2145): 2.51e-121: 430: 25.60		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		571636 SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		757502 MAP1B_HUMAN (491-2148): 1.27e-36: 155: 8.83		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		807662 MAP1B_HUMAN (491-2148): 1.27e-36: 155: 8.83		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		757674 ANKH1_HUMAN (88-992): 9.48e-35: 148: 14.15		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		757803 SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		892934 SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		1051936 PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		1271630 CIC_HUMAN (8-701): 6.41e-09: 63.9: 8.78		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		571557 CIC_HUMAN (8-701): 6.41e-09: 63.9: 8.78		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		757612 MDC1_HUMAN (907-2156): 1.96e-13: 78.7: 10.22		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		892945 PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		892878 CIC_HUMAN (8-701): 6.41e-09: 63.9: 8.78		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		640678 PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71