HitPredict

Interactor 1: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	25852190, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 541 Hs			1 292
+	Hs
		625220 TCPE_HUMAN (1-541): 0: 635: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		414817 TCPE_HUMAN (1-541): 0: 635: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		625228 TCPG_HUMAN (14-540): 0: 572: 33.15		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		625579 TCPH_HUMAN (12-539): 0: 570: 29.64		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		826623 TCPG_HUMAN (14-540): 0: 572: 33.15		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		960322 TCPH_HUMAN (12-539): 0: 570: 29.64		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		821179 TCPE_HUMAN (1-541): 0: 635: 100.00		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Hs
		415042 TCPH_HUMAN (12-539): 0: 570: 29.64		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		573132 TCPA_HUMAN (26-541): 0: 545: 32.08		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		573225 TCPA_HUMAN (26-541): 0: 545: 32.08		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414725 TCPA_HUMAN (26-541): 0: 545: 32.08		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Sc
		339699 TCPH_YEAST (7-540): 0: 542: 30.30		CDK1_YEAST (1-288): 1.39e-123: 356: 55.44
+	Hs
		826627 TCPG_HUMAN (14-540): 0: 572: 33.15		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Hs
		989714 TCPH_HUMAN (12-539): 0: 570: 29.64		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Hs
		573231 TCPA_HUMAN (26-541): 0: 545: 32.08		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Hs
		625246 TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		843162 TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414827 TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		843169 TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94