HitPredict

Interactor 1: K2C6C (P48668)
Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)
Gene: KRT6C

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 564 Hs			1 776
+	Hs
		380604 K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		380607 K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		380608 K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		380606 K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		318802 K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		409064 K2C8_HUMAN (135-511): 4.68e-165: 479: 68.70		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		380605 K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		380471 K2C6B_HUMAN (1-499): 1.95e-90: 290: 99.00		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		517775 K2C3_HUMAN (135-479): 5.47e-178: 518: 79.83		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		380662 K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		318805 K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		318806 K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1042632 KRT84_HUMAN (1-546): 3.99e-106: 332: 51.37		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		318804 K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		380472 K2C6B_HUMAN (1-499): 1.95e-90: 290: 99.00		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		318803 K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		943669 KRT85_HUMAN (1-528): 2.32e-89: 286: 47.73		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		821654 K2C6C_HUMAN (1-499): 5.3e-90: 289: 100.00		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		318858 K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		380508 K2C6B_HUMAN (1-499): 1.95e-90: 290: 99.00		CUL5_HUMAN (2-776): 0: 622: 28.85