HitPredict

Interactor 1: NEST (P48681)
Nestin
Gene: NES

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	12832492, 17036052
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0051402 - neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1621 Hs			1 292
+	Hs
		443339 VIME_HUMAN (8-343): 3.05e-118: 382: 28.32		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Rn
		597446 NEST_RAT (1-1289): 5.93e-53: 207: 43.01		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Hs
		528401 MYH8_HUMAN (570-1583): 2.91e-36: 153: 9.58		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		528405 MYH8_HUMAN (570-1583): 2.91e-36: 153: 9.58		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		213939 KRT86_HUMAN (6-313): 2.99e-63: 226: 21.34		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Hs
		318796 K2C75_HUMAN (6-319): 4.7e-60: 219: 21.43		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Hs
		522542 MYH1_HUMAN (549-1583): 5.34e-33: 142: 10.34		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		960128 MYH2_HUMAN (549-1583): 8.08e-33: 141: 9.95		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		960129 MYH13_HUMAN (549-1526): 1.29e-30: 134: 10.01		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		625176 MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		528368 MYH6_HUMAN (771-1488): 1.11e-23: 111: 7.35		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		502908 MYH3_HUMAN (771-1429): 7.51e-23: 109: 8.35		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		625440 NUMA1_HUMAN (818-1473): 5.43e-19: 96.5: 10.02		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		522604 MYH7_HUMAN (1-522): 5.76e-18: 93.1: 9.19		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		414709 GFAP_HUMAN (8-316): 8.2e-22: 102: 30.35		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		625177 MYH10_HUMAN (14-453): 1.66e-13: 78.4: 11.24		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		724717 MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Mm
		372930 GFAP_MOUSE (8-316): 1.55e-20: 98.6: 30.09		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Hs
		414801 PERI_HUMAN (8-343): 9.5e-15: 80.9: 27.87		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		725114 MYH10_HUMAN (14-453): 1.66e-13: 78.4: 11.24		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24