Protein: TMTC4
Protein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 4) (Transmembrane and tetratricopeptide repeat-containing 4)

Gene: TMTC4
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q5T4D3

Gene Ontology (top 5):
GO:0000030 - mannosyltransferase activity
GO:0004169 - dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0007605 - sensory perception of sound
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036208

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

2

High-throughput

0.861

High

828374

PEX19
Peroxisomal biogenesis factor 19

3

1

High-throughput

0.667

High

1212725

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

1

High-throughput

0.628

High

1212728

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

2

1

High-throughput

0.628

High

1212731

SCN3B
Sodium channel regulatory subunit beta-3

2

2

High-throughput

0.628

High

1212722

TXD15
Thioredoxin domain-containing protein 15

3

15

High-throughput

0.609

High

937539

CADH8
Cadherin-8

3

7

High-throughput

0.604

High

1212734

NGN3
Neurogenin-3

3

2

High-throughput

0.604

High

829898

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

1212718

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.602

High

170802

CLGN
Calmegin

2

11

High-throughput

0.601

High

1105474

OS9
Protein OS-9

2

0

High-throughput

0.595

High

384166

CO1A1
Collagen alpha-1(I) chain

2

0

High-throughput

0.585

High

652530

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

15

High-throughput

0.574

High

1194656

CCD40
Coiled-coil domain-containing protein 40

2

1

High-throughput

0.574

High

1212724

GORS1
Golgi reassembly-stacking protein 1

2

1

High-throughput

0.574

High

1212729

PCD12
Protocadherin-12

2

7

High-throughput

0.574

High

698748

CALX
Calnexin

1

11

High-throughput

0.536

High

851133

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

5

High-throughput

0.536

High

1212721

CREL1
Protein disulfide isomerase CRELD1

1

6

High-throughput

0.536

High

1212727

CAD23
Cadherin-23

1

2

High-throughput

0.536

High

1098627

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

1212716

OSTB
Organic solute transporter subunit beta

1

0

High-throughput

0.513

High

1212730

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.513

High

249929

NPHN
Nephrin

1

3

High-throughput

0.489

High

323998

CSTN1
Calsyntenin-1

1

13

High-throughput

0.489

High

326716

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.489

High

440592

FYN
Tyrosine-protein kinase Fyn

1

5

High-throughput

0.489

High

706156

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

789134

NUP62
Nuclear pore glycoprotein p62

1

10

High-throughput

0.489

High

877138

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.489

High

1088175

CAD17
Cadherin-17

1

14

High-throughput

0.489

High

1162796

H2A2C
Histone H2A type 2-C

1

1

High-throughput

0.489

High

1212714

LRC55
Leucine-rich repeat-containing protein 55

1

2

High-throughput

0.489

High

1212719

LRC15
Leucine-rich repeat-containing protein 15

1

1

High-throughput

0.489

High

1212733

SNX12
Sorting nexin-12

1

4

High-throughput

0.489

High

1212735

PCDGM
Protocadherin gamma-C5

1

5

High-throughput

0.489

High

413988

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

516673

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

2

High-throughput

0.445

High

1212732

FBX2
F-box only protein 2

1

4

High-throughput

0.445

High

1138966

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

7

High-throughput

0.437

High

1212720

SAAL1
Protein SAAL1

1

2

High-throughput

0.407

High

1212726

TGIF2
Homeobox protein TGIF2

1

1

High-throughput

0.407

High

1212736

PCDG5
Protocadherin gamma-A5

1

10

High-throughput

0.407

High

1212715

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

3

0

High-throughput

0.347

High

469496

SYPH
Synaptophysin

2

0

High-throughput

0.328

High

821727

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1212713

EST3
Carboxylesterase 3

2

0

High-throughput

0.324

High

1212717

OSTM1
Osteopetrosis-associated transmembrane protein 1

2

0

High-throughput

0.313

High

902382

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.279

Low

1212712

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

1212723

OPALI
Opalin

1

0

High-throughput

0.279

Low

956897

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025