HitPredict

Interactor 1: MASP1 (P48740)
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
Gene: MASP1

Interactor 2: FCN2 (Q15485)
Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)
Gene: FCN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 0.60 0.692

The method score is based on:

Property Details
Experiments 12421953, 19109177, 19939495, 21035894
Identification Methods pull down, surface plasmon resonance, enzyme linked immunosorbent assay, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001867 - complement activation, lectin pathway
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0048306 - calcium-dependent protein binding
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 699
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024