HitPredict

Interactor 1: TNNI2 (P48788)
Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
Gene: TNNI2

Interactor 2: TNNC1 (P63316)
Troponin C, slow skeletal and cardiac muscles (TN-C)
Gene: TNNC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	7103951, 33961781, 24333682
Identification Methods	x-ray crystallography, affinity chromatography technology, nuclear magnetic resonance, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	EF-hand_7~Troponin, EF-hand_8~Troponin
Common GO terms	GO:0003009 - skeletal muscle contraction GO:0005829 - cytosol GO:0005861 - troponin complex GO:0031014 - troponin T binding GO:0060048 - cardiac muscle contraction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 182 Hs			1 161
+	Hs
		581184 TNNI1_HUMAN (1-180): 7.31e-60: 186: 58.56		TNNC1_HUMAN (1-161): 1.1e-83: 244: 100.00
+	Hs
		584293 TNNI3_HUMAN (2-180): 3.45e-56: 177: 56.11		TNNC1_HUMAN (1-161): 1.1e-83: 244: 100.00
+	Gg
		455000 Q6S7R6_CHICK (2-180): 5e-53: 169: 50.56		TNNC1_CHICK (1-161): 5.83e-83: 243: 98.76
+	Oc
		361254 TNNI2_RABIT (1-182): 6.84e-63: 193: 96.15		TNNC2_RABIT (1-161): 6.82e-49: 156: 64.60
+	Hs
		361204 TNNI3_HUMAN (2-180): 3.45e-56: 177: 56.11		TNNC2_HUMAN (1-161): 7.69e-49: 156: 64.60
+	Hs
		361223 Q6FGX2_HUMAN (2-180): 3.45e-56: 177: 56.11		TNNC2_HUMAN (1-161): 7.69e-49: 156: 64.60
+	Dm
		734259 TNNI_DROME (8-144): 1.72e-26: 103: 30.22		CALL_DROME (9-154): 4.48e-24: 93.2: 40.41