HitPredict

Interactor 1: PAXI (P49023)
Paxillin
Gene: PXN

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	22761432, 9054445, 7534286, 8641358
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0017166 - vinculin binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 2541
+	Mm
		640172 FHL1_MOUSE (351-471): 2.28e-27: 113: 26.19		TLN1_MOUSE (1-2541): 0: 1536: 98.74
+	Hs
		823516 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		MACF1_HUMAN (404-2519): 9.43e-159: 555: 11.11
+	Hs
		719414 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		124424 ZFP1_HUMAN (236-414): 3.69e-22: 101: 7.18		HIP1_HUMAN (1798-2532): 2.31e-117: 402: 20.27
+	Hs
		719500 ZKSC8_HUMAN (76-467): 4.17e-45: 170: 9.74		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		1050799 FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87		E41L5_HUMAN (50-684): 9.18e-98: 335: 13.72
+	Hs
		823465 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82
+	Hs
		1087920 LPP_HUMAN (472-590): 5.36e-23: 105: 26.23		PTN21_HUMAN (64-973): 1.47e-87: 316: 12.49
+	Hs
		547168 LPP_HUMAN (472-590): 5.36e-23: 105: 26.23		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		719759 LPP_HUMAN (472-590): 5.36e-23: 105: 26.23		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		719522 ABLM2_HUMAN (532-590): 9.08e-09: 60.2: 27.12		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		816255 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		URP2_HUMAN (200-416): 3.61e-52: 199: 23.74
+	Hs
		150514 ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		150532 ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Ce
		954487 PXL1_CAEEL (143-532): 1.7e-57: 200: 19.75		HUM6_CAEEL (78-421): 4.37e-20: 100: 20.00
+	Hs
		1068675 PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52
+	Hs
		816268 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82
+	Ce
		104744 G5EFG1_CAEEL (473-590): 4.79e-32: 133: 35.00		G5EC35_CAEEL (1467-2539): 8.36e-09: 63.7: 9.78