HitPredict

Interactor 1: ERCC3 (P49135)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH 89 kDa subunit) (Xeroderma pigmentosum group B-complementing protein)
Gene: ERCC3

Interactor 2: SMAD5 (P97454)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (Dwarfin-C) (Dwf-C) (SMAD family member 5) (SMAD 5) (Smad5) (mSmad5)
Gene: SMAD5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	16101586
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 783 Mm			1 465
+	Mm
		824609 ERCC3_MOUSE (1-783): 0: 705: 100.00		SMAD1_MOUSE (3-465): 0: 636: 89.46
+	Mm
		824614 ERCC3_MOUSE (1-783): 0: 705: 100.00		SMAD9_MOUSE (2-465): 0: 586: 75.05
+	Hs
		584603 ERCC3_HUMAN (1-783): 0: 701: 95.79		SMAD2_HUMAN (4-465): 0: 540: 55.80
+	Hs
		571568 DDX5_HUMAN (234-756): 1.25e-105: 338: 12.09		SMAD5_HUMAN (1-465): 0: 653: 98.93
+	Hs
		571470 DDX5_HUMAN (234-756): 1.25e-105: 338: 12.09		SMAD1_HUMAN (3-465): 0: 636: 89.03
+	Mm
		936615 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD1_MOUSE (3-465): 0: 636: 89.46
+	Mm
		1207259 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD3_MOUSE (4-465): 0: 555: 58.12
+	Hs
		571401 DDX5_HUMAN (234-756): 1.25e-105: 338: 12.09		SMAD3_HUMAN (4-465): 0: 555: 58.12
+	Hs
		133977 DDX3X_HUMAN (202-678): 1.71e-100: 326: 11.11		SMAD3_HUMAN (4-465): 0: 555: 58.12
+	Mm
		1143947 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD2_MOUSE (4-465): 0: 542: 55.80
+	Hs
		181693 DDX3Y_HUMAN (192-678): 1.2e-98: 321: 11.30		SMAD3_HUMAN (4-465): 0: 555: 58.12
+	Hs
		181701 DDX3Y_HUMAN (192-678): 1.2e-98: 321: 11.30		SMAD2_HUMAN (4-465): 0: 540: 55.80
+	Mm
		956548 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD4_MOUSE (14-461): 1.72e-154: 451: 35.14
+	Mm
		192488 Q8BTS0_MOUSE (234-669): 2.4e-105: 338: 13.79		SMAD7_MOUSE (37-132): 2.17e-26: 112: 32.71