HitPredict

Interactor 1: MAPK2 (P49137)
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Gene: MAPKAPK2

Interactor 2: MAPK2 (P49137)
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Gene: MAPKAPK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.879

The method score is based on:

Property Details
Experiments 8995385, 18695677, 21675959, 20057052
Identification Methods enzymatic study, protein complementation assay, x-ray crystallography
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0002224 - toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
and 32 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 400
Hs

1 400
+ At
+ Gm
+ At
+ At
+ Hs
+ At
+ At
+ At
+ At
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024