Protein: VPS10
Vacuolar protein sorting/targeting protein VPS10 (Carboxypeptidase Y receptor) (CPY receptor) (Carboxypeptidase Y-deficient protein 1) (Sortilin VPS10) (Vacuolar carboxypeptidase sorting receptor VPS10) (Vacuolar protein sorting-associated protein 10) (Vacuolar protein-targeting protein 1)

Gene: VPS10, PEP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 59
UniProt ID: P32319

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000324 - fungal-type vacuole
GO:0000423 - mitophagy
GO:0000425 - pexophagy
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733796

VPS10
Vacuolar protein sorting/targeting protein VPS10

2

4

High-throughput

0.811

High

733798

VPS35
Vacuolar protein sorting-associated protein 35

2

2

Small-scale

0.614

High

733809

PEP8
Carboxypeptidase Y-deficient protein 8

2

1

Small-scale

0.614

High

733812

ATG27
Autophagy-related protein 27

2

1

High-throughput

0.614

High

733805

GGA2
ADP-ribosylation factor-binding protein GGA2

2

7

Small-scale

0.613

High

733830

VPS68
Vacuolar protein sorting-associated protein 68

2

0

High-throughput

0.588

High

733834

VPS5
Vacuolar protein sorting-associated protein 5

2

0

Small-scale

0.588

High

733821

ANY1
Scramblase ANY1

2

0

High-throughput

0.587

High

523319

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.571

High

544118

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.552

High

416870

CDC25
Cell division control protein 25

1

1

High-throughput

0.541

High

484273

KEX1
Pheromone-processing carboxypeptidase KEX1

1

0

High-throughput

0.518

High

644728

CLH
Clathrin heavy chain

1

0

High-throughput

0.518

High

733814

ENT3
Epsin-3

1

0

High-throughput

0.518

High

733833

LAS17
Proline-rich protein LAS17

1

1

High-throughput

0.489

High

733825

VTI1
t-SNARE VTI1

1

0

Small-scale

0.484

High

454284

CARP
Saccharopepsin

1

1

Small-scale

0.479

High

579018

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

649801

VPS34
Phosphatidylinositol 3-kinase VPS34

1

2

High-throughput

0.479

High

733819

BECN1
Vacuolar protein sorting-associated protein 30

1

1

High-throughput

0.479

High

733824

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

733831

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

646640

VPS15
Serine/threonine-protein kinase VPS15

1

0

High-throughput

0.458

High

733806

SNF7
Vacuolar-sorting protein SNF7

1

0

High-throughput

0.458

High

733813

VPS53
Vacuolar protein sorting-associated protein 53

1

0

Small-scale

0.458

High

733817

DID2
Vacuolar protein-sorting-associated protein 46

1

0

High-throughput

0.458

High

733828

ATG20
Autophagy-related protein 20

1

1

High-throughput

0.457

High

733804

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

733808

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

558631

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

603023

EST1
Telomere elongation protein EST1

1

2

High-throughput

0.437

High

609209

CLC1
Clathrin light chain

1

1

Small-scale

0.437

High

610114

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.437

High

705140

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

733800

CENPA
Histone H3-like centromeric protein CSE4

1

5

High-throughput

0.437

High

394334

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

733797

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.426

High

733829

TLG2
t-SNARE affecting a late Golgi compartment protein 2

1

0

Small-scale

0.426

High

381937

H4
Histone H4

1

1

High-throughput

0.407

High

733818

NOP3
Serine/arginine

2

0

High-throughput

0.324

High

733820

DIG1
Down-regulator of invasive growth 1

2

0

High-throughput

0.324

High

733799

DEF1
RNA polymerase II degradation factor 1

2

0

High-throughput

0.298

High

733802

FTH1
Iron transporter FTH1

1

0

High-throughput

0.282

High

733811

BUD27
Bud site selection protein 27

1

0

Small-scale

0.282

High

733823

TVP15
Golgi apparatus membrane protein TVP15

1

0

High-throughput

0.282

High

733832

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.269

Low

506436

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

706455

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

733801

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.249

Low

733803

ECM29
Proteasome component ECM29

1

0

High-throughput

0.249

Low

733810

SEC24
Protein transport protein SEC24

1

0

High-throughput

0.249

Low

733815

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

733816

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

733822

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

733826

SEC13
Protein transport protein SEC13

1

0

High-throughput

0.249

Low

733827

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.249

Low

471384

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.232

Low

733807

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025