HitPredict

Interactor 1: ARRB1 (P49407)
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Gene: ARRB1

Interactor 2: Q7Z3R3 (Q7Z3R3)
48 kDa protein
Gene: DKFZp686J1593

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	17620599
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Arrestin_C~Arrestin_C, Arrestin_C~Arrestin_N
Common GO terms	GO:0001664 - G protein-coupled receptor binding GO:0002031 - G protein-coupled receptor internalization GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 203
+	Hs
		827122 ARRB1_HUMAN (1-418): 0: 716: 100.00		ARRB1_HUMAN (2-185): 5.01e-104: 307: 63.30
+	Hs
		685845 ARRB1_HUMAN (1-418): 0: 716: 100.00		ARRB2_HUMAN (2-179): 2.22e-96: 287: 57.87
+	Hs
		489849 ARRB1_HUMAN (1-418): 0: 716: 100.00		ARRS_HUMAN (1-183): 4.43e-93: 279: 98.36
+	Mm
		1207384 ARRB1_MOUSE (1-418): 0: 703: 98.57		ARRB2_MOUSE (2-179): 1.16e-94: 283: 56.43
+	Hs
		736269 ARRB1_HUMAN (1-418): 0: 716: 100.00		ARRC_HUMAN (2-183): 8.1e-86: 259: 48.91
+	Hs
		685806 ARRB2_HUMAN (1-407): 0: 626: 76.15		ARRB2_HUMAN (2-179): 2.22e-96: 287: 57.87
+	Hs
		489848 ARRB2_HUMAN (1-407): 0: 626: 76.15		ARRS_HUMAN (1-183): 4.43e-93: 279: 98.36
+	Rn
		663949 ARRB2_RAT (1-407): 0: 616: 75.00		ARRB2_RAT (2-179): 9.43e-95: 283: 56.43
+	Hs
		685817 ARRB2_HUMAN (1-407): 0: 626: 76.15		ARRC_HUMAN (2-183): 8.1e-86: 259: 48.91
+	Bt
		436867 ARRS_BOVIN (6-408): 0: 566: 56.16		ARRS_BOVIN (1-180): 8.53e-97: 288: 90.56
+	Hs
		489847 ARRS_HUMAN (3-411): 0: 553: 56.07		ARRS_HUMAN (1-183): 4.43e-93: 279: 98.36
+	Mm
		593478 ARRS_MOUSE (3-408): 0: 553: 56.48		ARRS_MOUSE (1-183): 5.75e-91: 273: 89.07